Influence of a triclosan toothpaste on periodontopathic bacteria and periodontitis progression in cardiovascular patients: a randomized controlled trial

Seymour, G. J., Palmer, J. E., Leishman, S. J., Do, H. L., Westerman, B., Carle, A. D., Faddy, M. J., West, M. J. and Cullinan, M. P. (2016) Influence of a triclosan toothpaste on periodontopathic bacteria and periodontitis progression in cardiovascular patients: a randomized controlled trial. Journal of Periodontal Research, . doi:10.1111/jre.12369


Author Seymour, G. J.
Palmer, J. E.
Leishman, S. J.
Do, H. L.
Westerman, B.
Carle, A. D.
Faddy, M. J.
West, M. J.
Cullinan, M. P.
Title Influence of a triclosan toothpaste on periodontopathic bacteria and periodontitis progression in cardiovascular patients: a randomized controlled trial
Journal name Journal of Periodontal Research   Check publisher's open access policy
ISSN 1600-0765
0022-3484
Publication date 2016-03-02
Year available 2016
Sub-type Article (original research)
DOI 10.1111/jre.12369
Open Access Status Not Open Access
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Formatted abstract
Background and Objective: Triclosan/copolymer toothpaste is effective in controlling plaque and gingivitis and in slowing the progression of periodontitis. This study describes its influence on microbiological and clinical outcomes, over a 5-year period, in patients with established cardiovascular disease (CVD).

Material and Methods: Four-hundred and thirty-eight patients were recruited from the Cardiovascular Unit at The Prince Charles Hospital, Brisbane, Australia, and randomized to triclosan or placebo groups. Six sites per tooth were examined annually for probing pocket depth and loss of attachment. These outcomes were analysed, using generalized linear modelling, in 381 patients who had measurements from consecutive examinations. Concurrent load of the periodontal pathogens Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Tannerella forsythia and Porphyromonas gingivalis was determined, using quantitative real-time PCR, in 437 patients with baseline plaque samples. Group comparisons were expressed as geometric means. The chi-square test was used to test for differences between the two groups of patients with regard to the proportion of patients with different numbers of bacterial species.

Results: There was no difference in general health or periodontal status between the groups at baseline. There was a significant reduction in the number of interproximal sites showing loss of attachment between examinations, by 21% on average (p < 0.01), in the triclosan group compared with the placebo group. The prevalence of patients with F. nucleatum and A. actinomycetemcomitans was high and remained relatively constant throughout the 5 years of the study. In contrast, the prevalence of T. forsythia and P. gingivalis showed more variability; however, there was no significant difference between the groups, at any timepoint, in the prevalence of any organism. A significant difference in the geometric means for P. gingivalis (p = 0.01) was seen at years 1 and 4, and for F. nucleatum (p = 0.01) and in the total bacterial load (p = 0.03) at year 2; however, these differences were not statistically significant following a Bonferronicorrection for multiple comparisons. There was no difference between thegroups in the geometric means for each organism at year 5.

Conclusion: Within the limitations of the study, these data suggest that the useof triclosan/copolymer toothpaste significantly slowed the progression of peri-odontitis in patients with CVD but that it had little influence on key subgingivalperiodontopathic bacteria in these patients over the 5 years of the study.
Keyword Cardiovascular disease
Periodontitis
Periodontopathic bacteria
Randomized clinical trial
Triclosan toothpaste
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
School of Dentistry Publications
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 15 Mar 2016, 01:31:07 EST by System User on behalf of Learning and Research Services (UQ Library)