Polygenic risk of ischemic stroke is associated with cognitive ability

Harris, Sarah E., Malik, Rainer, Marioni, Riccardo, Campbell, Archie, Seshadri, Sudha, Worrall, Bradford B., Sudlow, Cathie L.M., Hayward, Caroline, Bastin, Mark E., Starr, John M., Porteous, David J., Wardlaw, Joanna M. and Deary, Ian J. (2016) Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology, 86 7: 611-618. doi:10.1212/WNL.0000000000002306

Author Harris, Sarah E.
Malik, Rainer
Marioni, Riccardo
Campbell, Archie
Seshadri, Sudha
Worrall, Bradford B.
Sudlow, Cathie L.M.
Hayward, Caroline
Bastin, Mark E.
Starr, John M.
Porteous, David J.
Wardlaw, Joanna M.
Deary, Ian J.
Title Polygenic risk of ischemic stroke is associated with cognitive ability
Journal name Neurology   Check publisher's open access policy
ISSN 1526-632X
Publication date 2016-02-16
Year available 2015
Sub-type Article (original research)
DOI 10.1212/WNL.0000000000002306
Open Access Status DOI
Volume 86
Issue 7
Start page 611
End page 618
Total pages 8
Place of publication Philadelphia, United States
Publisher Lippincott Williams and Wilkins
Collection year 2016
Language eng
Formatted abstract
Objectives: We investigated the correlation between polygenic risk of ischemic stroke (and its subtypes) and cognitive ability in 3 relatively healthy Scottish cohorts: the Lothian Birth Cohort 1936 (LBC1936), the Lothian Birth Cohort 1921 (LBC1921), and Generation Scotland: Scottish Family Health Study (GS).

Methods: Polygenic risk scores for ischemic stroke were created in LBC1936 (n = 1005), LBC1921 (n = 517), and GS (n = 6,815) using genome-wide association study summary data from the METASTROKE collaboration. We investigated whether the polygenic risk scores correlate with cognitive ability in the 3 cohorts.

Results: In the largest cohort, GS, polygenic risk of all ischemic stroke, small vessel disease stroke, and large vessel disease stroke, but not cardioembolic stroke, were correlated with both fluid and crystallized cognitive abilities. The highest correlation was between a polygenic risk score for all ischemic stroke and general cognitive ability (r = −0.070, p = 1.95 × 10−8). Few correlations were identified in LBC1936 and LBC1921, but a meta-analysis of all 3 cohorts supported the correlation between polygenic risk of ischemic stroke and cognitive ability.

Conclusions: The findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 22 December 2015

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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