Salivary epigenetic biomarkers in head and neck squamous cell carcinomas

Lim, Yenkai, Sun, Charles Xiaohang, Tran, Peter and Punyadeera, Chamindie (2016) Salivary epigenetic biomarkers in head and neck squamous cell carcinomas. Biomarkers in Medicine, 10 3: 301-313. doi:10.2217/bmm.16.2


Author Lim, Yenkai
Sun, Charles Xiaohang
Tran, Peter
Punyadeera, Chamindie
Title Salivary epigenetic biomarkers in head and neck squamous cell carcinomas
Journal name Biomarkers in Medicine   Check publisher's open access policy
ISSN 1752-0371
1752-0363
Publication date 2016-03-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/bmm.16.2
Open Access Status Not Open Access
Volume 10
Issue 3
Start page 301
End page 313
Total pages 13
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2017
Language eng
Abstract The early detection of head and neck squamous cell carcinoma (HNSCC) continues to be a challenge to the clinician. Saliva as a diagnostic medium carries significant advantages including its close proximity to the region of interest, ease of collection and noninvasive nature. While the identification of biomarkers continues to carry significant diagnostic and prognostic utility in HNSCC, epigenetic alterations present a novel opportunity to serve this purpose. With the developments of novel and innovative technologies, epigenetic alterations are now emerging as attractive candidates in HNSCC. As such, this review will focus on two commonly aberrant epigenetic alterations: DNA methylation and microRNA expression in HNSCC and their potential clinical utility. Identification and validation of these salivary epigenetic biomarkers would not only enable early diagnosis but will also facilitate in the clinical management.
Keyword DNA methylation
Epigenetic biomarkers
Head and neck squamous cell carcinoma
MicroRNA
Salivary diagnostics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Dentistry Publications
 
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