Factors associated with poor CD4 and viral load outcomes in patients with HIV/AIDS

Syed, Imran Ahmed, Sulaiman, Syed Azhar Syed, Hassali, Mohammad Azmi, Syed, Shahzad Hasan, Shan, Lau Hui and Lee, Christopher K. C. (2016) Factors associated with poor CD4 and viral load outcomes in patients with HIV/AIDS. Journal of Medical Virology, 88 5: 790-797. doi:10.1002/jmv.24389

Author Syed, Imran Ahmed
Sulaiman, Syed Azhar Syed
Hassali, Mohammad Azmi
Syed, Shahzad Hasan
Shan, Lau Hui
Lee, Christopher K. C.
Title Factors associated with poor CD4 and viral load outcomes in patients with HIV/AIDS
Journal name Journal of Medical Virology   Check publisher's open access policy
ISSN 1096-9071
Publication date 2016-05-01
Year available 2015
Sub-type Article (original research)
DOI 10.1002/jmv.24389
Open Access Status Not Open Access
Volume 88
Issue 5
Start page 790
End page 797
Total pages 8
Place of publication Hoboken NJ, United States
Publisher John Wiley & Sons
Collection year 2016
Language eng
Abstract Suboptimal viral suppression and CD4 response to antiretroviral treatment (HAART) is known to cause poor outcomes with the increase cost of treatment. We aimed to assess factors associated with such control among HIV/AIDS patients in Malaysia. Four hundred and six HIV/AIDS patients, using Antiretroviral Therapy (ART) for at least the past three months, treated as outpatients at medication therapy adherence clinics (MTAC) were recruited. CD4 cell counts, viral load readings along with co-variants such as socio-demographic factors, adverse drug reactions, comorbidities, and medication record were obtained. Statistical Package for Social Sciences (SPSS®) version 18 and STATA IC® version 12 were used for data analysis. CD4 counts were found highest among those within the age category 41–50 years (390.43 ± 272.28), female (402.64 ± 276.14), other ethnicities (400.20 ± 278.04), and participants with no formal education (414.87 ± 290.90). Patients experiencing adverse effects had a 2.28 (95%CI:1.25–4.18) fold greater risk of poor CD4 control, while patients with comorbidities had 2.46 (95%CI:1.02–5.91) fold greater risk of mild viral suppression. Adverse drug reactions, co-morbidities were found to be significantly associated with poor immunological and virological outcomes in HIV/AIDS patients. However, a comprehensive evaluation is needed to better understand other confounders.
Keyword HIV & AIDS
CD4 outcomes
Viral suppression
Factors associated
Anti-retroviral therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Pharmacy Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 15 Mar 2016, 00:16:57 EST by System User on behalf of School of Pharmacy