A meta-analysis of chemokines in major depression

Eyre, Harris A., Air, Tracy, Pradhan, Alyssa, Johnston, James, Lavretsky, Helen, Stuart, Michael J. and Baune, Bernhard T. (2016) A meta-analysis of chemokines in major depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 68 1-8. doi:10.1016/j.pnpbp.2016.02.006


Author Eyre, Harris A.
Air, Tracy
Pradhan, Alyssa
Johnston, James
Lavretsky, Helen
Stuart, Michael J.
Baune, Bernhard T.
Title A meta-analysis of chemokines in major depression
Journal name Progress in Neuro-Psychopharmacology and Biological Psychiatry   Check publisher's open access policy
ISSN 1878-4216
0278-5846
Publication date 2016-07-04
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.pnpbp.2016.02.006
Open Access Status Not Open Access
Volume 68
Start page 1
End page 8
Total pages 8
Place of publication Philadelphia, PA United States
Publisher Elsevier
Collection year 2017
Language eng
Abstract Chemokines are increasingly recognised as playing a role in depression. Here we meta-analyse the data on concentrations of all chemokines in patients diagnosed with a major depression versus healthy controls. We included studies which utilised Diagnostic and Statistical Manual (DSM)-IV diagnostic criteria for major depression, participants free from major medical conditions, studies with healthy controls, and unstimulated measurements of chemokines. We only included chemokines which had ≥ 3 studies performed. Two chemokines and 15 studies in total met criteria for this meta-analysis; 8 for Monocyte Chemotactic Protein (MCP)-1/CCL2 (n = 747), and 7 for Interleukin (IL)-8/CXCL8 (n = 560). There were significantly higher concentrations of CCL2/MCP-1 in depressed subjects compared with control subjects – overall mean difference of 36.43 pg/mL (95% CI: 2.43 to 70.42). There was significant heterogeneity across these studies (I2 = 98.5%). The estimates of mean difference between the control and depression groups did not remain significant when the trim-and-fill procedure was used to correct for publication bias. There was no significant difference in concentrations of IL-8/CXCL8 in depressed subjects compared with control subjects. Significant heterogeneity was found across these studies (I2 = 96.7%). The estimates of mean difference between the control and depression groups remained non-significant when the trim-and-fill procedure was used to correct for publication bias. This meta-analysis reports significantly heterogeneity in this field among studies. There are higher concentrations of the chemokine MCP-1/CCL2 in depressed subjects compared with control subjects, and no differences for IL-8/CXCL8. More high quality research and consistent methodologies are needed in this important area of enquiry.
Keyword Chemokine
Depression
Diagnosis
Cytokine
Inflammation
Mood disorder
Meta-analysis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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