Effects of a low-glycemic index diet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial

Kizirian, Nathalie V., Kong, Yang, Muirhead, Roslyn, Brodie, Shannon, Garnett Sarah P., Petocz, Peter, Sim, Kyra A., Celermajer, David S., Louie, Jimmy C. Y., Markovic, Tania P., Ross, Glynis P., Ward, Leigh C., Brand-Miller, Jennie C. and Skilton, Michael R. (2016) Effects of a low-glycemic index diet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial. American Journal of Clinical Nutrition, 103 4: 1073-1082. doi:10.3945/ajcn.115.123695


Author Kizirian, Nathalie V.
Kong, Yang
Muirhead, Roslyn
Brodie, Shannon
Garnett Sarah P.
Petocz, Peter
Sim, Kyra A.
Celermajer, David S.
Louie, Jimmy C. Y.
Markovic, Tania P.
Ross, Glynis P.
Ward, Leigh C.
Brand-Miller, Jennie C.
Skilton, Michael R.
Title Effects of a low-glycemic index diet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 1938-3207
0002-9165
Publication date 2016-04
Year available 2016
Sub-type Article (original research)
DOI 10.3945/ajcn.115.123695
Open Access Status Not Open Access
Volume 103
Issue 4
Start page 1073
End page 1082
Total pages 10
Place of publication Bethesda, MD United States
Publisher American Society for Nutrition
Collection year 2017
Language eng
Formatted abstract
Background: Elevated maternal blood glucose concentrations may contribute to macrosomia, adiposity, and poorer vascular health in the offspring.

Objective: The aim was to explore the effect of a low–glycemic index (low-GI) diet during pregnancy on offspring growth, adiposity, and arterial wall thickness during infancy.

Design: This was a longitudinal follow-up study in a self-selected subgroup of mother-infant pairs (n = 59) participating in a larger randomized trial comparing the effects on perinatal outcomes of a low-GI diet and a conventional high-fiber (HF) diet during pregnancy. Infant anthropometric measurements were taken every month for 6 mo and then at 9 and 12 mo of age. Adiposity was assessed at birth and at 3 mo by air-displacement plethysmography by using the Pea Pod system (Cosmed) and at 6 and 12 mo by bioimpedance analysis (Bodystat). Aortic intima-media thickness was assessed at 12 mo by high-resolution ultrasound (Philips).

Results: Maternal dietary GI was lower in the low-GI group than in the HF group (51 ± 1 compared with 57 ± 1; P < 0.001). No differences in neonatal outcomes were observed in the main trial. In the self-selected subsample, birth weight and length z scores were lower in the low-GI group than in the HF group (birth weight z score: 0.2 ± 0.2 compared with 0.7 ± 0.2, respectively; P = 0.04; birth length z score: 0.3 ± 0.2 compared with 0.9 ± 0.2, respectively; P = 0.04), but adiposity from birth to 12 mo of age and growth trajectories from 1 to 12 mo of age were similar. Aortic intima-media thickness was lower in the low-GI group than in the HF group (657 ±12 compared with 696 ± 12 μm, respectively; P = 0.02), which was partly mediated by differences in birth weight.

Conclusion: In women at risk of gestational diabetes mellitus, a low-GI diet influences offspring birth weight, birth length, and arterial wall thickness in early childhood, but not adiposity or growth trajectory during the first year of life. This trial was registered at anzctr.org.au as ACTRN12610000681055.
Keyword Body composition
Gestational diabetes mellitus
Glycemic index
Infant
Intima-media thickness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 11 Mar 2016, 12:30:42 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences