Probiotics as antifungals in mucosal candidiasis

Matsubara, Victor H., Bandara, H. M. H. N., Mayer, Marcia P. A. and Samaranayake, Lakshman P. (2016) Probiotics as antifungals in mucosal candidiasis. Clinical Infectious Diseases, 62 9: 1143-1153. doi:10.1093/cid/ciw038

Author Matsubara, Victor H.
Bandara, H. M. H. N.
Mayer, Marcia P. A.
Samaranayake, Lakshman P.
Title Probiotics as antifungals in mucosal candidiasis
Journal name Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1537-6591
Publication date 2016-05
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/cid/ciw038
Volume 62
Issue 9
Start page 1143
End page 1153
Total pages 11
Place of publication Cary, United States
Publisher Oxford University Press
Collection year 2017
Language eng
Formatted abstract
Candida is an opportunistic pathogen that causes mucosal and deep systemic candidiasis. The emergence of drug resistance and the side effects of currently available antifungals have restricted their use as long-term prophylactic agents for candidal infections. Given this scenario, probiotics have been suggested as a useful alternative for the management of candidiasis. We analyzed the available data on the efficacy of probiotics in candidal colonization of host surfaces. A number of well-controlled studies indicate that probiotics, particularly lactobacilli, suppress Candida growth and biofilm development in vitro. A few clinical trials have also shown the beneficial effects of probiotics in reducing oral, vaginal, and enteric colonization by Candida; alleviation of clinical signs and symptoms; and, in some cases, reducing the incidence of invasive fungal infection in critically ill patients. Probiotics may serve in the future as a worthy ally in the battle against chronic mucosal candidal infections.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Dentistry Publications
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Created: Thu, 10 Mar 2016, 17:25:31 EST by Nihal Bandara on behalf of School of Dentistry