The effects of nasal continuous positive airway pressure on cardiac function in premature infants with minimal lung disease: a crossover randomized trial

Beker, Friederike, Rogerson, Sheryle R., Hooper, Stuart B., Wong, Connie and Davis, Peter G. (2014) The effects of nasal continuous positive airway pressure on cardiac function in premature infants with minimal lung disease: a crossover randomized trial. Journal of Pediatrics, 164 4: 726-729. doi:10.1016/j.jpeds.2013.10.087


Author Beker, Friederike
Rogerson, Sheryle R.
Hooper, Stuart B.
Wong, Connie
Davis, Peter G.
Title The effects of nasal continuous positive airway pressure on cardiac function in premature infants with minimal lung disease: a crossover randomized trial
Journal name Journal of Pediatrics   Check publisher's open access policy
ISSN 0022-3476
1097-6833
Publication date 2014-04
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jpeds.2013.10.087
Open Access Status Not Open Access
Volume 164
Issue 4
Start page 726
End page 729
Total pages 4
Place of publication Philadelphia, United States
Publisher Mosby
Language eng
Formatted abstract
Objective
To assess the effects of different nasal continuous positive airway pressure (nCPAP) pressures on cardiac performance in preterm infants with minimal lung disease, we conducted a randomized, blinded crossover study.

Study design
We studied infants between 28 and 34 weeks' corrected gestational age, treated with nCPAP of 5 cm H2O, in air. Infants with significant cardiac shunts were excluded. Infants were randomly assigned to nCPAP levels of 4, 6, and 8 cm H2O for 15 minutes each. Right and left ventricular outputs and left pulmonary artery and superior vena cava flows were measured 15 minutes after each change.

Results
Thirty-four infants born at a mean gestational age of 29 weeks with a birth weight of 1.3 kg were studied. There were no significant differences in right and left ventricular outputs and left pulmonary artery and superior vena cava flows at different levels of nCPAP.

Conclusion
We investigated the effect of increasing nCPAP levels on cardiac output. We conclude that nCPAP levels between 4 and 8 cm H2O did not have an effect on cardiac output in stable preterm infants with minimal lung disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 09 Mar 2016, 15:20:14 EST by Friederike Beker on behalf of Paediatrics & Child Health - Mater Hospital