Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Moradi, Shayli Varasteh, Hussein, Waleed M., Varamini, Pegah, Simerska, Pavla and Toth, Istvan (2016) Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides. Chemical Science, 7 4: 2492-2500. doi:10.1039/C5SC04392A


Author Moradi, Shayli Varasteh
Hussein, Waleed M.
Varamini, Pegah
Simerska, Pavla
Toth, Istvan
Title Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
Journal name Chemical Science   Check publisher's open access policy
ISSN 2041-6539
2041-6520
Publication date 2016-01-29
Sub-type Article (original research)
DOI 10.1039/C5SC04392A
Open Access Status DOI
Volume 7
Issue 4
Start page 2492
End page 2500
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2017
Language eng
Formatted abstract
Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes. This review highlights various methods for the synthesis of glycoconjugates and recent progress in the development of glycosylated peptide therapeutics. Furthermore, the impacts of glycosylation in overcoming the existing barriers that restrict oral and brain delivery of peptides are described herein.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 09 Mar 2016, 14:53:30 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences