A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases

Lew-Tabor, A. E. and Rodriguez Valle, M. (2016) A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases. Ticks and Tick-borne Diseases, 7 4: 573-585. doi:10.1016/j.ttbdis.2015.12.012


Author Lew-Tabor, A. E.
Rodriguez Valle, M.
Title A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases
Journal name Ticks and Tick-borne Diseases   Check publisher's open access policy
ISSN 1877-959X
1877-9603
Publication date 2016-06
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ttbdis.2015.12.012
Open Access Status Not Open Access
Volume 7
Issue 4
Start page 573
End page 585
Total pages 13
Place of publication Munich, Germany
Publisher Elsevier
Collection year 2016
Language eng
Abstract The field of reverse vaccinology developed as an outcome of the genome sequence revolution. Following the introduction of live vaccinations in the western world by Edward Jenner in 1798 and the coining of the phrase ‘vaccine’, in 1881 Pasteur developed a rational design for vaccines. Pasteur proposed that in order to make a vaccine that one should ‘isolate, inactivate and inject the microorganism’ and these basic rules of vaccinology were largely followed for the next 100 years leading to the elimination of several highly infectious diseases. However, new technologies were needed to conquer many pathogens which could not be eliminated using these traditional technologies. Thus increasingly, computers were used to mine genome sequences to rationally design recombinant vaccines. Several vaccines for bacterial and viral diseases (i.e. meningococcus and HIV) have been developed, however the on-going challenge for parasite vaccines has been due to their comparatively larger genomes. Understanding the immune response is important in reverse vaccinology studies as this knowledge will influence how the genome mining is to be conducted. Vaccine candidates for anaplasmosis, cowdriosis, theileriosis, leishmaniasis, malaria, schistosomiasis, and the cattle tick have been identified using reverse vaccinology approaches. Some challenges for parasite vaccine development include the ability to address antigenic variability as well the understanding of the complex interplay between antibody, mucosal and/or T cell immune responses. To understand the complex parasite interactions with the livestock host, there is the limitation where algorithms for epitope mining using the human genome cannot directly be adapted for bovine, for example the prediction of peptide binding to major histocompatibility complex motifs. As the number of genomes for both hosts and parasites increase, the development of new algorithms for pan-genomic mining will continue to impact the future of parasite and ricketsial (and other tick borne pathogens) disease vaccine development.
Keyword Reverse vaccinology
Ticks
Tick borne diseases
Veterinary
Vaccines
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 18 December 2015

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2016 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 08 Mar 2016, 11:26:38 EST by Dr Manuel Rodriguez Valle on behalf of Centre for Animal Science