Ultrasound treatment of neurological diseases — current and emerging applications

Leinenga, Gerhard, Langton, Christian, Nisbet, Rebecca and Gotz, Jurgen (2016) Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 3: 161-174. doi:10.1038/nrneurol.2016.13


Author Leinenga, Gerhard
Langton, Christian
Nisbet, Rebecca
Gotz, Jurgen
Title Ultrasound treatment of neurological diseases — current and emerging applications
Journal name Nature Reviews Neurology   Check publisher's open access policy
ISSN 1759-4766
1759-4758
Publication date 2016-02-19
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrneurol.2016.13
Open Access Status Not Open Access
Volume 12
Issue 3
Start page 161
End page 174
Total pages 14
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Abstract Like cardiovascular disease and cancer, neurological disorders present an increasing challenge for an ageing population. Whereas nonpharmacological procedures are routine for eliminating cancer tissue or opening a blocked artery, the focus in neurological disease remains on pharmacological interventions. Setbacks in clinical trials and the obstacle of access to the brain for drug delivery and surgery have highlighted the potential for therapeutic use of ultrasound in neurological diseases, and the technology has proved useful for inducing focused lesions, clearing protein aggregates, facilitating drug uptake, and modulating neuronal function. In this Review, we discuss milestones in the development of therapeutic ultrasound, from the first steps in the 1950s to recent improvements in technology. We provide an overview of the principles of diagnostic and therapeutic ultrasound, for surgery and transient opening of the blood-brain barrier, and its application in clinical trials of stroke, Parkinson disease and chronic pain. We discuss the promising outcomes of safety and feasibility studies in preclinical models, including rodents, pigs and macaques, and efficacy studies in models of Alzheimer disease. We also consider the challenges faced on the road to clinical translation.
Keyword Drug delivery
Neurological disorders
Neurosurgery
Ultrasound
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Centre for Ageing Dementia Research Publications
 
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