Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment

Cheng, Feifei, Zhao, Lu, Wu, Yuanyuan, Huang, Tiantian, Yang, Gangyi, Zhang, Zhanyu, Wu, Yijia, Jia, Fang, Wu, Jinlin, Chen, Chen and Liu, Dongfang (2016) Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. Clinical Endocrinology, 84 3: 386-393. doi:10.1111/cen.12950


Author Cheng, Feifei
Zhao, Lu
Wu, Yuanyuan
Huang, Tiantian
Yang, Gangyi
Zhang, Zhanyu
Wu, Yijia
Jia, Fang
Wu, Jinlin
Chen, Chen
Liu, Dongfang
Title Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment
Journal name Clinical Endocrinology   Check publisher's open access policy
ISSN 1365-2265
0300-0664
Publication date 2016-03
Year available 2015
Sub-type Article (original research)
DOI 10.1111/cen.12950
Open Access Status Not Open Access
Volume 84
Issue 3
Start page 386
End page 393
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Objective To determine serum vascular endothelial growth factor B (VEGF-B) levels in polycystic ovary syndrome, their association with insulin resistance and β-cell dysfunction, and the effect of metformin on serum VEGF-B levels.
Design A cross-sectional, interventional study.
Patients We recruited 103 women with polycystic ovary syndrome and 96 age-matched healthy controls. Serum VEGF-B levels were determined in all participants, and 44 polycystic ovary syndrome patients randomly received metformin.
Measurements We measured VEGF-B levels in healthy controls and women with polycystic ovary syndrome before and after metformin treatment.
Results Women with polycystic ovary syndrome had higher serum VEGF-B levels, which decreased with metformin treatment. In the lean and overweight/obese groups, patients with polycystic ovary syndrome had higher plasma VEGF-B levels than did healthy controls (P < 0·05). VEGF-B levels were correlated with body mass index, body fat percentage, M values, homeostasis model assessment of insulin resistance and β-cell function indices. A multiple linear regression analysis showed that VEGF-B level was associated with M values after adjusting for age, body mass index, serum sex hormones and serum lipids in women with polycystic ovary syndrome.
Conclusions Serum VEGF-B is significantly higher in women with polycystic ovary syndrome and is closely and positively related to insulin resistance. Metformin treatment reduces VEGF-B levels and ameliorates insulin resistance.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 15 October 2015

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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