Epigenetics and peripheral artery disease

Golledge, Jonathan, Biros, Erik, Bingley, John, Iyer, Vikram and Krishna, Smriti M. (2016) Epigenetics and peripheral artery disease. Current Atherosclerosis Reports, 18 4: 15.1-15.9. doi:10.1007/s11883-016-0567-4


Author Golledge, Jonathan
Biros, Erik
Bingley, John
Iyer, Vikram
Krishna, Smriti M.
Title Epigenetics and peripheral artery disease
Journal name Current Atherosclerosis Reports   Check publisher's open access policy
ISSN 1534-6242
1523-3804
Publication date 2016-02-18
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11883-016-0567-4
Open Access Status Not Open Access
Volume 18
Issue 4
Start page 15.1
End page 15.9
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Springer Healthcare
Collection year 2017
Language eng
Abstract The term epigenetics is usually used to describe inheritable changes in gene function which do not involve changes in the DNA sequence. These typically include non-coding RNAs, DNA methylation and histone modifications. Smoking and older age are recognised risk factors for peripheral artery diseases, such as occlusive lower limb artery disease and abdominal aortic aneurysm, and have been implicated in promoting epigenetic changes. This brief review describes studies that have associated epigenetic factors with peripheral artery diseases and investigations which have examined the effect of epigenetic modifications on the outcome of peripheral artery diseases in mouse models. Investigations have largely focused on microRNAs and have identified a number of circulating microRNAs associated with human peripheral artery diseases. Upregulating or antagonising a number of microRNAs has also been reported to limit aortic aneurysm development and hind limb ischemia in mouse models. The importance of DNA methylation and histone modifications in peripheral artery disease has been relatively little studied. Whether circulating microRNAs can be used to assist identification of patients with peripheral artery diseases and be modified in order to improve the outcome of peripheral artery disease will require further investigation.
Keyword Abdominal aortic aneurysm
DNA methylation
Epigenetics
MicroRNAs
Peripheral artery disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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