A coiled-coil region of an insect immune suppressor protein is involved in binding and uptake by hemocytes

Asgari, S. and Schmidt, O. (2002) A coiled-coil region of an insect immune suppressor protein is involved in binding and uptake by hemocytes. Insect Biochemistry And Molecular Biology, 32 5: 497-504.


Author Asgari, S.
Schmidt, O.
Title A coiled-coil region of an insect immune suppressor protein is involved in binding and uptake by hemocytes
Journal name Insect Biochemistry And Molecular Biology   Check publisher's open access policy
ISSN 0965-1748
Publication date 2002-05
Sub-type Article (original research)
DOI 10.1016/S0965-1748(01)00127-8
Volume 32
Issue 5
Start page 497
End page 504
Total pages 8
Place of publication Oxford
Publisher Elsevier Science Ltd
Language eng
Abstract Polydnaviruses are associated with certain parasitoid wasps and are introduced into the body cavity of the host caterpillar during oviposition. Some of the viral genes are expressed in host tissues and corresponding proteins are secreted into the hemocoel causing suppression of the host immune system. The Cotesia rubecula polydnavirus gene product, CrV1, effectively inactivates hemocytes by mediating cytoskeleton break-down. A precondition for the CrV1 function is the incorporation of the extracellular protein by hemocytes. Here, we show that a coiled-coil domain containing a putative leucine zipper is required for CrV1 function, since removal of this domain abolishes binding and uptake of the CrV1 protein by hemocytes. (C) 2002 Elsevier Science Ltd. All rights reserved.
Keyword Biochemistry & Molecular Biology
Entomology
Immunosuppressor
Uptake
Polydnavirus
Coiled-coil Domain
Lipophorin
Receptor-mediated Endocytosis
Polydnavirus Dna
Lipoprotein
Expression
Hemolymph
Wasp
Persistence
Braconidae
Sequences
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biological Sciences Publications
 
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Created: Mon, 13 Aug 2007, 12:56:23 EST