Robust T1-weighted structural brain imaging and morphometry at 7T using MP2RAGE

O'Brien, Kieran R., Kober, Tobias, Hagmann, Patric, Maeder, Philippe, Marques, Jose, Lazeyras, Francois, Krueger, Gunnar and Roche, Alexis (2014) Robust T1-weighted structural brain imaging and morphometry at 7T using MP2RAGE. PLoS ONE, 9 6: . doi:10.1371/journal.pone.0099676

Author O'Brien, Kieran R.
Kober, Tobias
Hagmann, Patric
Maeder, Philippe
Marques, Jose
Lazeyras, Francois
Krueger, Gunnar
Roche, Alexis
Title Robust T1-weighted structural brain imaging and morphometry at 7T using MP2RAGE
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-06-16
Sub-type Article (original research)
DOI 10.1371/journal.pone.0099676
Open Access Status DOI
Volume 9
Issue 6
Total pages 7
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Abstract Purpose: To suppress the noise, by sacrificing some of the signal homogeneity for numerical stability, in uniform T1 weighted (T1w) images obtained with the magnetization prepared 2 rapid gradient echoes sequence (MP2RAGE) and to compare the clinical utility of these robust T1w images against the uniform T1w images. Materials and Methods: 8 healthy subjects (29.0±4.1 years; 6 Male), who provided written consent, underwent two scan sessions within a 24 hour period on a 7T head-only scanner. The uniform and robust T1w image volumes were calculated inline on the scanner. Two experienced radiologists qualitatively rated the images for: general image quality; 7T specific artefacts; and, local structure definition. Voxel-based and volume-based morphometry packages were used to compare the segmentation quality between the uniform and robust images. Statistical differences were evaluated by using a positive sided Wilcoxon rank test. Results: The robust image suppresses background noise inside and outside the skull. The inhomogeneity introduced was ranked as mild. The robust image was significantly ranked higher than the uniform image for both observers (observer 1/2, p-value = 0.0006/0.0004). In particular, an improved delineation of the pituitary gland, cerebellar lobes was observed in the robust versus uniform T1w image. The reproducibility of the segmentation results between repeat scans improved (pvalue = 0.0004) from an average volumetric difference across structures of ≈6.6% to ≈2.4% for the uniform image and robust T1w image respectively. Conclusions: The robust T1w image enables MP2RAGE to produce, clinically familiar T1w images, in addition to T1 maps, which can be readily used in uniform morphometry packages.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
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