Neuronal cell-type-specific alternative splicing: A mechanism for specifying connections in the brain?

Li, Joshua Shing Shun, Shin, Grace Ji-eun and Millard, Sean S. (2015) Neuronal cell-type-specific alternative splicing: A mechanism for specifying connections in the brain?. Neurogenesis, 2 1: e1122699.1-e1122699.5. doi:10.1080/23262133.2015.1122699


Author Li, Joshua Shing Shun
Shin, Grace Ji-eun
Millard, Sean S.
Title Neuronal cell-type-specific alternative splicing: A mechanism for specifying connections in the brain?
Journal name Neurogenesis
ISSN 2326-2125
2326-2133
Publication date 2015
Sub-type Article (original research)
DOI 10.1080/23262133.2015.1122699
Open Access Status DOI
Volume 2
Issue 1
Start page e1122699.1
End page e1122699.5
Total pages 5
Place of publication New York, NY, United States
Publisher Taylor & Francis
Collection year 2016
Language eng
Abstract Alternative splicing (AS) allows a single gene to generate multiple protein isoforms. It has been hypothesized that AS plays a role in brain wiring by increasing the number of cell recognition molecules necessary for forming connections between neurons. Many studies have characterized isoform expression patterns of various genes in the brain, but very few have addressed whether specific isoforms play a functional role in neuronal wiring. In our recent work, we reported the cell-type-specific AS of the cell recognition molecule Dscam2. Exclusive expression of Dscam2 isoforms allows tightly associated neurons to signal repulsion selectively within the same cell-types, without interfering with one another. We show that preventing cell-specific isoform expression in 2 closely associated neurons disrupts their axon terminal morphology. We propose that the requirement for isoform specificity extends to synapses and discuss experiments that can test this directly. Factors that regulate Dscam2 cell-type-specific AS likely regulate the splicing of many genes involved in neurodevelopment. These regulators of alternative splicing may act broadly to control many genes involved in the development of specific neuron types. Identifying these factors is a key step in understanding how AS contributes to the brain connectome.
Keyword Alternative splicing
Cell-type-specific
Dscam2
Dscam1
Dscam
Neuronal wiring
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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Created: Fri, 04 Mar 2016, 09:39:07 EST by Ms Joanne Biles on behalf of School of Biomedical Sciences