The association between HbA1c and cardiovascular disease markers in a remote Indigenous Australian community with and without diagnosed diabetes

Arnold, Luke W., Hoy, Wendy E., Sharma, Suresh K. and Wang, Zhiqiang (2016) The association between HbA1c and cardiovascular disease markers in a remote Indigenous Australian community with and without diagnosed diabetes. Journal of Diabetes Research, 2016 5342304: 1-8. doi:10.1155/2016/5342304


Author Arnold, Luke W.
Hoy, Wendy E.
Sharma, Suresh K.
Wang, Zhiqiang
Title The association between HbA1c and cardiovascular disease markers in a remote Indigenous Australian community with and without diagnosed diabetes
Journal name Journal of Diabetes Research   Check publisher's open access policy
ISSN 2314-6753
2314-6745
Publication date 2016-02-18
Year available 2016
Sub-type Article (original research)
DOI 10.1155/2016/5342304
Open Access Status DOI
Volume 2016
Issue 5342304
Start page 1
End page 8
Total pages 8
Place of publication London, United Kingdom
Publisher Hindawi Publishing Corporation
Collection year 2017
Language eng
Formatted abstract
Objectives. This study investigates the burden of cardiovascular risk markers in people with and without diabetes in a remote Indigenous Australian community, based on their HbA1c concentration. Methods. This study included health screening exams of 1187 remote Indigenous residents over 15 years old who represented 70% of the age-eligible community. The participants were stratified by HbA1c into 5 groups using cut-off points recommended by international organisations. The associations of traditional cardiovascular risk markers with HbA1c groups were assessed using logistic and linear regressions and ANOVA models. Results. Of the 1187 participants, 158 (13%) had a previous diabetes diagnosis, up to 568 (48%) were at high risk (5.7–6.4% (39–46 mmol/mol) HbA1c), and 67 (6%) potential new cases of diabetes (≥6.5% (48 mmol/mol)) were identified. Individuals with higher HbA1c levels were more likely to have albuminuria (OR 3.14, 95% CI 1.26–7.82) and dyslipidaemia (OR 2.37, 95% CI 1.29–4.34) and visited the clinic more often (OR 2.52, 95% CI 1.26–4.99). Almost all traditional CVD risk factors showed a positive association with HbA1c. Conclusions. Screening in this remote Indigenous Australian community highlights the high proportion of individuals who are at high risk of diabetes as indicated by HbA1c and who also had an accentuated cardiovascular risk profile.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 02 Mar 2016, 15:12:37 EST by Luke Arnold on behalf of Medicine - Royal Brisbane and Women's Hospital