Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls

Ekman, C., Elgzyri, T., Strom, K., Almgren, P., Parikh, H., Nitert, Marloes Dekker, Ronn, T., Koivula, Fiona Manderson, Ling, C., Tornberg, A. B., Wollmer, P., Eriksson, K. F., Groop, L. and Hansson, O. (2015) Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls. Journal of Applied Physiology, 119 9: 953-960. doi:10.1152/japplphysiol.01067.2014

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Author Ekman, C.
Elgzyri, T.
Strom, K.
Almgren, P.
Parikh, H.
Nitert, Marloes Dekker
Ronn, T.
Koivula, Fiona Manderson
Ling, C.
Tornberg, A. B.
Wollmer, P.
Eriksson, K. F.
Groop, L.
Hansson, O.
Title Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 1522-1601
Publication date 2015-11-01
Sub-type Article (original research)
DOI 10.1152/japplphysiol.01067.2014
Open Access Status Not Open Access
Volume 119
Issue 9
Start page 953
End page 960
Total pages 8
Place of publication Bethesda, United States
Publisher American Physiological Society
Collection year 2016
Language eng
Formatted abstract
Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility compared with subjects without heredity for diabetes (FH−). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response to exercise compared with FH−. Sixteen FH+ and 19 FH− insulin-sensitive men similar in age, peak oxygen consumption (V̇o2 peak), and body mass index completed an exercise intervention with heart rate monitored during exercise for 7 mo. Before and after the exercise intervention, the participants underwent a physical examination and tests for glucose tolerance and exercise capacity, and muscle biopsies were taken for expression analysis. The participants attended, on average, 39 training sessions during the intervention and spent 18.8 MJ on exercise. V̇o2 peak/kg increased by 14%, and the participants lost 1.2 kg of weight and 3 cm waist circumference. Given that the FH+ group expended 61% more energy during the intervention, we used regression analysis to analyze the response in the FH+ and FH− groups separately. Exercise volume had a significant effect on V̇o2 peak, weight, and waist circumference in the FH− group, but not in the FH+ group. After exercise, expression of genes involved in metabolism, oxidative phosphorylation, and cellular respiration increased more in the FH− compared with the FH+ group. This suggests that healthy, insulin-sensitive FH+ and FH− participants with similar age, V̇o2 peak, and body mass index may respond differently to an exercise intervention. The FH+ background might limit muscle adaptation to exercise, which may contribute to the increased susceptibility to type 2 diabetes in FH+ individuals.
Keyword Exercise intervention
Expression analysis
Genetic predisposition
Type 2 diabetes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
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Created: Wed, 02 Mar 2016, 10:14:54 EST by Matthew Lamb on behalf of School of Medicine