CD8+ T-cell responses before and after structured treatment interruption in Ugandan adults who initiated ART with CD4+ T cells <200 Cell/μL: the DART trial STI substudy

Serwanga, Jennifer, Mugaba, Susan, Betty, Auma, Pimego, Edward, Walker, Sarah, Munderi, Paula, Gilks, Charles, Gotch, Frances, Grosskurth, Heiner and Kaleebu, Pontiano (2011) CD8+ T-cell responses before and after structured treatment interruption in Ugandan adults who initiated ART with CD4+ T cells <200 Cell/μL: the DART trial STI substudy. AIDS Research and Treatment, 2011 875028: 1-10. doi:10.1155/2011/875028


Author Serwanga, Jennifer
Mugaba, Susan
Betty, Auma
Pimego, Edward
Walker, Sarah
Munderi, Paula
Gilks, Charles
Gotch, Frances
Grosskurth, Heiner
Kaleebu, Pontiano
Title CD8+ T-cell responses before and after structured treatment interruption in Ugandan adults who initiated ART with CD4+ T cells <200 Cell/μL: the DART trial STI substudy
Journal name AIDS Research and Treatment   Check publisher's open access policy
ISSN 2090-1240
2090-1259
Publication date 2011
Sub-type Article (original research)
DOI 10.1155/2011/875028
Open Access Status DOI
Volume 2011
Issue 875028
Start page 1
End page 10
Total pages 10
Place of publication New York, NY United States
Publisher Hindawi Publishing Corporation
Language eng
Formatted abstract
Objective. To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed. Methods. CD8+ T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial. Magnitudes, breadths, and functionality of IFN-γ and Perforin responses were compared in STI (n=42) and continuous treatment (CT) (n=46) before and after a single STI cycle when the DART STI trial was stopped early due to inferior clinical outcome in STI participants. Results. STI and CT had comparable magnitudes and breadths of monofunctional CD8+IFNγ+ and CD8+Perforin+ responses. However, STI was associated with significant decline in breadth of bi-functional (CD8+IFNγ+Perforin+) responses; P=.02, Mann-Whitney test. Conclusions. STI in individuals initiated onto ART at <200 CD4+ T-cell counts/μl significantly reduced occurrence of bifunctional CD8+IFNγ+/Perforin+ responses. These data add to others that found no evidence to support STI as a strategy to improve HIV-specific immunity during ART.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 02 Mar 2016, 09:35:36 EST by Charles Gilks on behalf of School of Public Health