Chlorotoxin: structure, activity, and potential uses in cancer therapy

Ojeda, Paola G., Wang, Conan K. and Craik, David J. (2016) Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers - Peptide Science, 106 1: 25-36. doi:10.1002/bip.22748


Author Ojeda, Paola G.
Wang, Conan K.
Craik, David J.
Title Chlorotoxin: structure, activity, and potential uses in cancer therapy
Journal name Biopolymers - Peptide Science   Check publisher's open access policy
ISSN 1097-0282
0006-3525
Publication date 2016-01-27
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/bip.22748
Open Access Status Not Open Access
Volume 106
Issue 1
Start page 25
End page 36
Total pages 12
Place of publication Hoboken, NJ United States
Publisher John Wiley & Sons
Collection year 2017
Language eng
Abstract Chlorotoxin is a disulfide-rich stable peptide from the venom of the Israeli scorpion Leiurus quinquestriatus, which has potential therapeutic applications in the treatment of cancer. Its ability to preferentially bind to tumor cells has been harnessed to develop an imaging agent to help visualize tumors during surgical resection. In addition, chlorotoxin has attracted interest as a vehicle to deliver anti-cancer drugs specifically to cancer cells. Given its interesting structural and biological properties, chlorotoxin also has the potential to be used in a variety of other biotechnology and biomedical applications. Here, we review the structure, activity and potential applications of chlorotoxin as a drug design scaffold.
Keyword Scorpion venom
Peptides
Cancer
Drug delivery
Drug development
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 01 Mar 2016, 13:48:46 EST by Susan Allen on behalf of Institute for Molecular Bioscience