Effects of exposure to Bovine viral diarrhoea virus 1 on risk of bovine respiratory disease in Australian feedlot cattle

Hay, K. E., Ambrose, R. C. K., Morton, J. M., Horwood, P. F., Gravel, J. L., Waldron, S., Commins, M. A., Fowler, E. V., Clements, A. C. A., Barnes, T. S. and Mahony, T. J. (2016) Effects of exposure to Bovine viral diarrhoea virus 1 on risk of bovine respiratory disease in Australian feedlot cattle. Preventive Veterinary Medicine, 126 159-169. doi:10.1016/j.prevetmed.2016.01.025


Author Hay, K. E.
Ambrose, R. C. K.
Morton, J. M.
Horwood, P. F.
Gravel, J. L.
Waldron, S.
Commins, M. A.
Fowler, E. V.
Clements, A. C. A.
Barnes, T. S.
Mahony, T. J.
Title Effects of exposure to Bovine viral diarrhoea virus 1 on risk of bovine respiratory disease in Australian feedlot cattle
Journal name Preventive Veterinary Medicine   Check publisher's open access policy
ISSN 0167-5877
1873-1716
Publication date 2016-02-01
Sub-type Article (original research)
DOI 10.1016/j.prevetmed.2016.01.025
Open Access Status Not Open Access
Volume 126
Start page 159
End page 169
Total pages 11
Place of publication Amsterdam, NX, Netherlands
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Viruses play a key role in the complex aetiology of bovine respiratory disease (BRD). Bovine viral diarrhoea virus 1 (BVDV-1) is widespread in Australia and has been shown to contribute to BRD occurrence. As part of a prospective longitudinal study on BRD, effects of exposure to BVDV-1 on risk of BRD in Australian feedlot cattle were investigated. A total of 35,160 animals were enrolled at induction (when animals were identified and characteristics recorded), held in feedlot pens with other cattle (cohorts) and monitored for occurrence of BRD over the first 50 days following induction. Biological samples collected from all animals were tested to determine which animals were persistently infected (PI) with BVDV-1. Data obtained from the Australian National Livestock Identification System database were used to determine which groups of animals that were together at the farm of origin and at 28 days prior to induction (and were enrolled in the study) contained a PI animal and hence to identify animals that had probably been exposed to a PI animal prior to induction. Multi-level Bayesian logistic regression models were fitted to estimate the effects of exposure to BVDV-1 on the risk of occurrence of BRD.

Although only a total of 85 study animals (0.24%) were identified as being PI with BVDV-1, BVDV-1 was detected on quantitative polymerase chain reaction in 59% of cohorts. The PI animals were at moderately increased risk of BRD (OR 1.9; 95% credible interval 1.0–3.2). Exposure to BVDV-1 in the cohort was also associated with a moderately increased risk of BRD (OR 1.7; 95% credible interval 1.1–2.5) regardless of whether or not a PI animal was identified within the cohort. Additional analyses indicated that a single quantitative real-time PCR test is useful for distinguishing PI animals from transiently infected animals.

The results of the study suggest that removal of PI animals and/or vaccination, both before feedlot entry, would reduce the impact of BVDV-1 on BRD risk in cattle in Australian feedlots. Economic assessment of these strategies under Australian conditions is required.
Keyword Bovine respiratory disease
Bovine viral diarrhoea virus 1
Feedlot cattle
Persistent infection
QPCR
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 01 Mar 2016, 03:48:08 EST by System User on behalf of Learning and Research Services (UQ Library)