Overexpression of ephrin A3 receptor in canine prostatic carcinoma

Hood, G., Laufer-Amorim, R., Fonseca-Alves, C. E. and Palmieri, C. (2016) Overexpression of ephrin A3 receptor in canine prostatic carcinoma. Journal of Comparative Pathology, 154 2-3: 180-185. doi:10.1016/j.jcpa.2016.01.002


Author Hood, G.
Laufer-Amorim, R.
Fonseca-Alves, C. E.
Palmieri, C.
Title Overexpression of ephrin A3 receptor in canine prostatic carcinoma
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 1532-3129
0021-9975
Publication date 2016-02
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.jcpa.2016.01.002
Open Access Status Not Open Access
Volume 154
Issue 2-3
Start page 180
End page 185
Total pages 5
Place of publication London United Kingdom
Publisher Elsevier
Collection year 2017
Language eng
Abstract Ephrin A3 (EphA3), a member of the ephrin receptor tyrosine kinase family, is involved in a variety of functions in normal cells, especially during embryonic development, and alterations in its expression profile have been observed in several human cancers. However, there are no reports of the expression of EphA3 in normal, hyperplastic or neoplastic canine prostate tissue or in other types of canine tumours. Six normal, 15 hyperplastic and 21 neoplastic canine prostates were examined immunohistochemically with a polyclonal antibody specific for human EphA3. The percentage of positive cells in all prostatic carcinomas was increased, with a mean of 89.28 ± 5.18% compared with normal (9.17 ± 6.72%) and hyperplastic prostates (20.00 ± 8.28%). EphA3 expression was not correlated with the histological subtypes of prostate cancer or with the Gleason score. The increase in EphA3 expression in canine prostatic carcinomas suggests the involvement of this receptor in prostatic carcinogenesis and its potential use as a target for new therapeutic strategies.
Keyword Cancer
Dog
EphA3
Prostate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Veterinary Science Publications
 
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