Retinal tissue thickness in type 1 and type 2 diabetes

Srinivasan, Sangeetha, Pritchard, Nicola, Sampson, Geoff P., Edwards, Katie, Vagenas, Dimitrios, Russell, Anthony W., Malik, Rayaz A. and Efron, Nathan (2016) Retinal tissue thickness in type 1 and type 2 diabetes. Clinical and Experimental Optometry, 99 1: 78-83. doi:10.1111/cxo.12318


Author Srinivasan, Sangeetha
Pritchard, Nicola
Sampson, Geoff P.
Edwards, Katie
Vagenas, Dimitrios
Russell, Anthony W.
Malik, Rayaz A.
Efron, Nathan
Title Retinal tissue thickness in type 1 and type 2 diabetes
Journal name Clinical and Experimental Optometry   Check publisher's open access policy
ISSN 1444-0938
0816-4622
Publication date 2016-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/cxo.12318
Open Access Status Not Open Access
Volume 99
Issue 1
Start page 78
End page 83
Total pages 6
Place of publication Chichester, West Sussex United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Formatted abstract
Background
The objective was to investigate full retinal and inner retinal thickness in individuals with type 1 and type 2 diabetes.

Methods
Eighty-four individuals with type 1 diabetes (T1DM), 67 individuals with type 2 diabetes (T2DM) and 42 non-diabetic individuals (control group) were enrolled. Participants underwent full retinal thickness evaluation in the central retinal, parafoveal and perifoveal zones and in the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC), using spectral domain optical coherence tomography. As a preliminary step, the key variables of interest – age, sex, diabetic retinopathy (DR), duration of diabetes and HbA1c levels – were analysed and compared between the three groups. Full retinal thickness, RNFL and GCC thicknesses were also compared between the groups. The relationship between the type of diabetes and retinal tissue thickness was explored, adjusting for the five potential confounders.

Results
Compared to individuals with T1DM, individuals with T2DM had significantly reduced full retinal thickness in the parafovea and perifovea and reduced RNFL and GCC thickness. The mean differences were six (p = 0.020), seven (p = 0.008), six (p = 0.021) and four micrometres (p = 0.013) for the parafovea, perifovea, RNFL and GCC thicknesses, respectively. Thicknesses within the central zone (p = 0.018) and at the parafovea (p = 0.007) were significantly reduced in T2DM when compared to the control group. After adjusting for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels, the relationship between type of diabetes and retinal tissue thickness was not statistically significant (p > 0.056).

Conclusion
Retinal tissue thickness is not significantly different between type 1 and type 2 diabetes, when adjusted for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels.
Keyword Diabetic retinopathy
Ganglion cell complex
Retinal nerve fibre layer
Retinal thickness
Type 1 diabetes
Type 2 diabetes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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