Heritability of naevus patterns in an adult twin cohort from the Brisbane Twin Registry: A cross-sectional study

Lee, S., Duffy, D.L., Mcclenahan, P., Lee, K. J., McEniery, E., Burke, B., Jagirdar, K., Martin, N.G., Sturm, R.A., Soyer, H.P. and Schaider, H. (2016) Heritability of naevus patterns in an adult twin cohort from the Brisbane Twin Registry: A cross-sectional study. British Journal of Dermatology, 174 2: 356-363. doi:10.1111/bjd.14291


Author Lee, S.
Duffy, D.L.
Mcclenahan, P.
Lee, K. J.
McEniery, E.
Burke, B.
Jagirdar, K.
Martin, N.G.
Sturm, R.A.
Soyer, H.P.
Schaider, H.
Title Heritability of naevus patterns in an adult twin cohort from the Brisbane Twin Registry: A cross-sectional study
Journal name British Journal of Dermatology   Check publisher's open access policy
ISSN 1365-2133
0007-0963
Publication date 2016-02
Year available 2016
Sub-type Article (original research)
DOI 10.1111/bjd.14291
Open Access Status Not Open Access
Volume 174
Issue 2
Start page 356
End page 363
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Formatted abstract
Background
Heritability of naevi counts is widely acknowledged as a potential surveillance parameter for prevention purposes. The contribution of heritability to the changes seen in naevus number and morphology over time and their corresponding dermoscopic characteristics is unknown, but is important to understand in order to account for adequate prevention measures.

Objectives

To identify naevus characteristics that are strongly influenced by heritability.

Methods
This cross-sectional study included 220 individuals [76 monozygotic (MZ), 144 dizygotic (DZ)], recruited from the Brisbane Twin Naevus Study. Participants received full body imaging and dermoscopy of naevi ≥ 5 mm in diameter. Dermoscopic type, total naevus count (TNC), change in TNC with age, and naevus distribution, size, colour and profile were compared between MZ and DZ twins. Heritability of these traits was assessed via Falconer's estimate.

Results
Significant differences were found in comparing MZ and DZ twins for TNC, numbers of naevi 5·0–7·9 mm in diameter, counts of light-brown naevi, naevi on the back and sun-protected sites, and naevi with the ‘nonspecific’ dermoscopic pattern.

Conclusions
This study strongly supports a heritable component to TNC, as well as changes in TNC, and the number of medium-sized naevi, light-brown naevi, specific sites and certain dermoscopic features in adults. These characteristics should be taken into account by naevus surveillance programmes and further studied to identify candidate gene associations for clinical and dermoscopic patterns in conjunction with melanoma risk stratification.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 01 Mar 2016, 01:13:00 EST by System User on behalf of Learning and Research Services (UQ Library)