The curious world of gonadal development in mammals

Koopman, Peter (2016) The curious world of gonadal development in mammals. Current Topics in Developmental Biology, 116 537-545. doi:10.1016/bs.ctdb.2015.12.009


Author Koopman, Peter
Title The curious world of gonadal development in mammals
Journal name Current Topics in Developmental Biology   Check publisher's open access policy
ISSN 0070-2153
1557-8933
ISBN 978-0-12-802956-5
Publication date 2016-02-17
Year available 2016
Sub-type Article (original research)
DOI 10.1016/bs.ctdb.2015.12.009
Open Access Status Not Open Access
Volume 116
Start page 537
End page 545
Total pages 9
Place of publication Maryland Heights, United States
Publisher Academic Press
Collection year 2017
Language eng
Formatted abstract
The distinct sex phenotypes of male and female hinge on the development of the fetal gonads as testes or ovaries, in turn, regulated by the molecular genetic machinery of sex determination. Here, I discuss five aspects of mammalian gonadal development that distinguish it from other examples of organogenesis, and continue to surprise and fascinate.

Let's face it: males and females are very different animals—so much so, that for any species there are really two developmental biologies, not one. Humans have been intrigued by the differences between men and women since the beginning of recorded history, and presumably long before. As a developmental biologist, it is especially fascinating to ask how the differences between the sexes arise. Finding the answers involves a stimulating mix of molecular genetics, cell biology, and developmental anatomy. Since our sex phenotype depends critically on the formation of testes or ovaries in the embryo, research efforts focus largely on the genetic control of sex determination and the organogenesis of the gonads. After half a lifetime, I am still busy delving into these issues. In this chapter, I attempt to rationalize this enduring fascination by describing five aspects of sex development that continue to captivate.
Keyword Ovary
Sex determination
Sry
Testis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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