Immunomics: a 21st century approach to vaccine development for complex pathogens

de Sousa, Karina P. and Doolan, Denise L. (2016) Immunomics: a 21st century approach to vaccine development for complex pathogens. Parasitology, 143 2: 236-244. doi:10.1017/S0031182015001079

Author de Sousa, Karina P.
Doolan, Denise L.
Title Immunomics: a 21st century approach to vaccine development for complex pathogens
Journal name Parasitology   Check publisher's open access policy
ISSN 1469-8161
Publication date 2016-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.1017/S0031182015001079
Open Access Status Not Open Access
Volume 143
Issue 2
Start page 236
End page 244
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2017
Language eng
Formatted abstract
Immunomics is a relatively new field of research which integrates the disciplines of immunology, genomics, proteomics, transcriptomics and bioinformatics to characterize the host-pathogen interface. Herein, we discuss how rapid advances in molecular immunology, sophisticated tools and molecular databases are facilitating in-depth exploration of the immunome. In our opinion, an immunomics-based approach presides over traditional antigen and vaccine discovery methods that have proved ineffective for highly complex pathogens such as the causative agents of malaria, tuberculosis and schistosomiasis that have evolved genetic and immunological host-parasite adaptations over time. By using an integrative multidisciplinary approach, immunomics offers enormous potential to advance 21st century antigen discovery and rational vaccine design against complex pathogens such as the Plasmodium parasite.
Keyword Immunomics
Antigen discovery
Rational vaccine design
Vaccine development
Complex pathogens
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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