ABCD: anthropometry, body composition and Crohnʼs disease

Brookes, Denise S. K., Briody, Julie N., Davies, Peter S.W. and Hill, Rebecca J. (2016) ABCD: anthropometry, body composition and Crohnʼs disease. Journal of Pediatric Gastroenterology and Nutrition, 63 1: 113-117. doi:10.1097/MPG.0000000000001135


Author Brookes, Denise S. K.
Briody, Julie N.
Davies, Peter S.W.
Hill, Rebecca J.
Title ABCD: anthropometry, body composition and Crohnʼs disease
Journal name Journal of Pediatric Gastroenterology and Nutrition   Check publisher's open access policy
ISSN 1536-4801
0277-2116
Publication date 2016-07
Sub-type Article (original research)
DOI 10.1097/MPG.0000000000001135
Open Access Status Not Open Access
Volume 63
Issue 1
Start page 113
End page 117
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2017
Language eng
Formatted abstract
Background: Young individuals with Crohn disease (CD) are at risk of poor bone mineral density (BMD) and reduced lean tissue mass (LTM). The importance of LTM for maintaining skeletal health, in both incident and established CD, is evidenced. We used dual-energy x-ray absorptiometry assessment to identify areal BMD and LTM in individuals with CD.
Methods: In 57 patients with CD (15F; 12.99–14.16 years) anthropometric, disease activity, bone age assessment, and total body dual-energy x-ray absorptiometry measurements were acquired. A 4-step algorithm was used to assess simultaneous bone and body composition data: areal BMD and height z scores, and LTM for height and bone mineral content (BMC) for LTM z scores were calculated. Low z score cut-off values were defined as <=1 standard deviations below the population means.
Results: The CD cohort showed: low areal BMD z scores (P = 0.00); and low LTM for height (P = 0.00) according to defined cut-off values. BMC appeared to be adapting for the lower amount of LTM. Correcting for bone age eliminated the low areal BMD z scores. As expected, LTM for height and BMC for LTM z scores remained unchanged.
Conclusions: We present a useful clinical algorithm to show significant LTM for height deficits, regardless of chronological or bone age, in this CD cohort. BMC seemed to adapt to the reduced LTM, indicating clinically “normal” areal BMD for age when considered for height. The ongoing deficits in LTM may, however, create chronic long-term consequences for bone health. Improving LTM should be a focus of clinical treatment in individuals with CD.
Keyword Bone mineral density
Children
Crohn disease
Dual-energy x-ray absorptiometry
Lean tissue mass
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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