C3 and 2D C3 Marfey’s methods for amino acid analysis in natural products

Vijayasarathy, Soumini, Prasad, Pritesh, Fremlin, Leith J., Ratnayake, Ranjala, Salim, Angela A., Khalil, Zeinab and Capon, Robert J. (2016) C3 and 2D C3 Marfey’s methods for amino acid analysis in natural products. Journal of Natural Products, 79 2: 421-427. doi:10.1021/acs.jnatprod.5b01125


Author Vijayasarathy, Soumini
Prasad, Pritesh
Fremlin, Leith J.
Ratnayake, Ranjala
Salim, Angela A.
Khalil, Zeinab
Capon, Robert J.
Title C3 and 2D C3 Marfey’s methods for amino acid analysis in natural products
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 1520-6025
0163-3864
Publication date 2016-02-10
Sub-type Article (original research)
DOI 10.1021/acs.jnatprod.5b01125
Open Access Status DOI
Volume 79
Issue 2
Start page 421
End page 427
Total pages 7
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2017
Language eng
Formatted abstract
We validate the improved resolution and sensitivity of the C3 Marfey’s method, including an ability to resolve all Ile isomers, against an array of amino acids commonly encountered in natural products and by comparison to an existing Marfey’s method. We also describe an innovative 2D C3 Marfey’s method as an analytical approach for determining the regiochemistry of enantiomeric amino acid residues in natural products. The C3 and 2D C3 Marfey’s methods represent valuable tools for probing and defining the stereocomplexity of hydrolytically accessible amino acid residues in natural products.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 29 Feb 2016, 15:53:13 EST by Soumini Vijayasarathy on behalf of National Res Centre For Environmental Toxicology