Organs-on-a-chip: a new tool for drug discovery

Polini, Alessandro, Prodanov, Ljupcho, Bhise, Nupura S., Manoharan, Vijayan, Dokmeci, Mehmet R. and Khademhosseini, Ali (2014) Organs-on-a-chip: a new tool for drug discovery. Expert Opinion on Drug Discovery, 9 4: 335-352. doi:10.1517/17460441.2014.886562


Author Polini, Alessandro
Prodanov, Ljupcho
Bhise, Nupura S.
Manoharan, Vijayan
Dokmeci, Mehmet R.
Khademhosseini, Ali
Title Organs-on-a-chip: a new tool for drug discovery
Journal name Expert Opinion on Drug Discovery   Check publisher's open access policy
ISSN 1746-045X
1746-0441
Publication date 2014-03-12
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/17460441.2014.886562
Open Access Status Not Open Access
Volume 9
Issue 4
Start page 335
End page 352
Total pages 18
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
Introduction: The development of emerging in vitro tissue culture platforms can be useful for predicting human response to new compounds, which has been traditionally challenging in the field of drug discovery. Recently, several in vitro tissue-like microsystems, also known as 'organs-on-a-chip', have emerged to provide new tools for better evaluating the effects of various chemicals on human tissue.

Areas covered: The aim of this article is to provide an overview of the organs-on-a-chip systems that have been recently developed. First, the authors introduce single-organ platforms, focusing on the most studied organs such as liver, heart, blood vessels and lung. Later, the authors briefly describe tumor-on-a-chip platforms and highlight their application for testing anti-cancer drugs. Finally, the article reports a few examples of other organs integrated in microfluidic chips along with preliminary multiple-organs-on-a- chip examples. The article also highlights key fabrication points as well as the main application areas of these devices.

Expert opinion: This field is still at an early stage and major challenges need to be addressed prior to the embracement of these technologies by the pharmaceutical industry. To produce predictive drug screening platforms, several organs have to be integrated into a single microfluidic system representative of a humanoid. The routine production of metabolic biomarkers of the organ constructs, as well as their physical environment, have to be monitored prior to and during the delivery of compounds of interest to be able to translate the findings into useful discoveries.
Keyword Biomimicry
Body-on-a-chip
Drug discovery platforms
In vitro models
In vitro reactors
Metabolic biomarkers
Microenvironment
Microfluidics
Organs-on-a-chip
Sensors
Tissue engineering
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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