Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.

Qayum, Mughal, Nisar, Muhammad, Shah, Muhammad Raza, Adhikari, Achyut, Kaleem, Waqar Ahmad, Khan, Inamullah, Khan, Nematullah, Gul, Farah, Khan, Ihsan Ali, Zia-ul-Haq, M. and Khan, Abad (2012) Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.. Phytotherapy Research, 26 4: 552-556. doi:10.1002/ptr.3574


Author Qayum, Mughal
Nisar, Muhammad
Shah, Muhammad Raza
Adhikari, Achyut
Kaleem, Waqar Ahmad
Khan, Inamullah
Khan, Nematullah
Gul, Farah
Khan, Ihsan Ali
Zia-ul-Haq, M.
Khan, Abad
Title Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.
Formatted title
Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.
Journal name Phytotherapy Research   Check publisher's open access policy
ISSN 0951-418X
1099-1573
Publication date 2012-04
Sub-type Article (original research)
DOI 10.1002/ptr.3574
Open Access Status Not Open Access
Volume 26
Issue 4
Start page 552
End page 556
Total pages 5
Place of publication Chichester, West Sussex United Kingdom
Publisher John Wiley & Sons
Language eng
Formatted abstract
A study was conducted to identify constituents that might be responsible for analgesic and antiinflammatory conditions. Tasumatrol B, 1,13-diacetyl-10-deacetylbaccatin III (10-DAD) and 4-deacetylbaccatin III (4-DAB) were isolated from the bark extract of Taxus wallichiana Zucc. All the compounds were assessed for analgesic and antiinflammatory activities using an acetic acid-induced writhing model, a hot-plate test, a carrageenan-induced paw oedema model, a cotton-pellet oedema model and in vitro lipoxygenase inhibitory assay. All the compounds, especially tasumatrol B, revealed significant analgesic activity in comparison to a saline group based on an acetic acid-induced model. Similarly all of the test compounds, particularly tasumatrol B, showed significant antiinflammatory activity. However, all the compounds failed to exhibit any considerable activity in of the hot-plate test and the in vitro lipoxygenase inhibitory assay. This study has highlighted the potential of tasumatrol B to be further explored as a new lead compound for the management of pain and inflammation, one that has been discovered by scientific validation of the traditional medicinal use of T. wallichiana Zucc.
Keyword Analgesic
Antiinflammatory
Lipoxygenase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Integrated Preclinical Drug Development Publications
 
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