Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica

Chuah, Candy, Jones, Malcolm K., McManus, Donald P., Nawaratna, Sujeevi K., Burke, Melissa L., Owen, Helen C., Ramm, Grant A. and Gobert, Geoffrey N. (2016) Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica. International Journal for Parasitology, 46 4: 239-252. doi:10.1016/j.ijpara.2015.12.004


Author Chuah, Candy
Jones, Malcolm K.
McManus, Donald P.
Nawaratna, Sujeevi K.
Burke, Melissa L.
Owen, Helen C.
Ramm, Grant A.
Gobert, Geoffrey N.
Title Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica
Journal name International Journal for Parasitology   Check publisher's open access policy
ISSN 1879-0135
0020-7519
Publication date 2016-04
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.ijpara.2015.12.004
Open Access Status Not Open Access
Volume 46
Issue 4
Start page 239
End page 252
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
For hepatic schistosomiasis the egg-induced granulomatous response and the development of extensive fibrosis are the main pathologies. We used a Schistosoma japonicum-infected mouse model to characterise the multi-cellular pathways associated with the recovery from hepatic fibrosis following clearance of the infection with the anti-schistosomal drug, praziquantel. In the recovering liver splenomegaly, granuloma density and liver fibrosis were all reduced. Inflammatory cell infiltration into the liver was evident, and the numbers of neutrophils, eosinophils and macrophages were significantly decreased. Transcriptomic analysis revealed the up-regulation of fatty acid metabolism genes and the identification of Peroxisome proliferator activated receptor alpha as the upstream regulator of liver recovery. The aryl hydrocarbon receptor signalling pathway which regulates xenobiotic metabolism was also differentially up-regulated. These findings provide a better understanding of the mechanisms associated with the regression of hepatic schistosomiasis.
Keyword Schistosomiasis
Hepatic fibrosis
Helminth
Transcriptomics
Liver recovery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Veterinary Science Publications
 
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