Cancer stem cell markers in prostate cancer: An immunohistochemical study of ALDH1, SOX2 and EZH2

Matsika, Admire, Srinivasan, Bhuvana, Day, Christopher, Mader, Sabina Ann, Kiernan, Deirdre Margaret, Broomfield, Amy, Fu, Jinlin, Hooper, John D., Kench, James G. and Samaratunga, Hemamali (2015) Cancer stem cell markers in prostate cancer: An immunohistochemical study of ALDH1, SOX2 and EZH2. Pathology, 47 7: 622-628. doi:10.1097/PAT.0000000000000325

Author Matsika, Admire
Srinivasan, Bhuvana
Day, Christopher
Mader, Sabina Ann
Kiernan, Deirdre Margaret
Broomfield, Amy
Fu, Jinlin
Hooper, John D.
Kench, James G.
Samaratunga, Hemamali
Title Cancer stem cell markers in prostate cancer: An immunohistochemical study of ALDH1, SOX2 and EZH2
Journal name Pathology   Check publisher's open access policy
ISSN 1465-3931
Publication date 2015-12
Sub-type Article (original research)
DOI 10.1097/PAT.0000000000000325
Open Access Status Not Open Access
Volume 47
Issue 7
Start page 622
End page 628
Total pages 7
Place of publication London, United Kingdom
Publisher Lippincott Williams & Wilkins
Collection year 2016
Language eng
Formatted abstract
Summary:  The aims of this study were to investigate the immunohistochemical expression and potential prognostic significance of putative cancer stems cell markers ALDH1, EZH2 and SOX2 in prostate cancer.
A total of 142 consecutive radical prostatectomies submitted to one laboratory with a diagnosis of prostatic adenocarcinoma between 2008 and 2012 were retrieved and retrospectively studied. Immunohistochemistry for the three markers was performed in each case and both univariate and multivariate analyses were undertaken to evaluate the correlation between the staining patterns and known histopathological prognostic features.
ALDH1 showed a statistically significant association with tumour stage p < 0.001), extraprostatic extension (p < 0.001) and lymphovascular invasion (p = 0.001). EZH2 correlated with Gleason score (p = 0.044) and lymph node metastases (p = 0.023). SOX2 showed a statistically significant correlation with lymphovascular invasion only (p = 0.018) in both univariate and multivariate analyses.
Cancer stem cell markers are variably expressed in prostate adenocarcinoma and immunohistochemical staining for ALDH1 and EZH2 may have a role in predicting tumour aggressiveness before treatment of prostate cancer.
Keyword Adenocarcinoma
Androgen receptor
Cancer stem cell theory
Cancer stem cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
School of Medicine Publications
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