Murine gammaherpesvirus 68 open reading frame 11 encodes a nonessential virion component

Boname, Jessica M., May, Janet S. and Stevenson, Philip G. (2005) Murine gammaherpesvirus 68 open reading frame 11 encodes a nonessential virion component. Journal of Virology, 79 5: 3163-3168. doi:10.1128/JVI.79.5.3163-3168.2005

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Author Boname, Jessica M.
May, Janet S.
Stevenson, Philip G.
Title Murine gammaherpesvirus 68 open reading frame 11 encodes a nonessential virion component
Journal name Journal of Virology
ISSN 1098-5514
1070-6321
Publication date 2005-03
Sub-type Article (original research)
DOI 10.1128/JVI.79.5.3163-3168.2005
Open Access Status File (Publisher version)
Volume 79
Issue 5
Start page 3163
End page 3168
Total pages 6
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
Open reading frame 11 (ORF11) is a conserved gammaherpesvirus gene that remains undefined. We identified the product of murine gammaherpesvirus 68 (MHV-68) ORF11, p43, as a virion component with a predominantly perinuclear distribution in infected cells. MHV-68 lacking p43 grew normally in vitro but showed reduced lytic replication in vivo and a delay in seeding to the spleen. Subsequent latency amplification was normal. Thus, MHV-68 ORF11 encoded a virion component that was important for in vivo lytic replication but dispensable for the establishment of latency.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 22 Feb 2016, 12:15:21 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences