Chronic promethazine misuse and the possibility of dependence: a brief review of antihistamine abuse and dependence

Parker, Stephen D., De Gioannia, Angelo and Page, Colin (2013) Chronic promethazine misuse and the possibility of dependence: a brief review of antihistamine abuse and dependence. Journal of Substance Use, 18 3: 238-241. doi:10.3109/14659891.2012.707285


Author Parker, Stephen D.
De Gioannia, Angelo
Page, Colin
Title Chronic promethazine misuse and the possibility of dependence: a brief review of antihistamine abuse and dependence
Journal name Journal of Substance Use   Check publisher's open access policy
ISSN 1465-9891
1475-9942
Publication date 2013-04-01
Sub-type Article (original research)
DOI 10.3109/14659891.2012.707285
Open Access Status Not Open Access
Volume 18
Issue 3
Start page 238
End page 241
Total pages 4
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
Objective: Misuse of centrally acting antihistamines is potentially a significant under-recognised issue contributing to problems of abuse and dependence, with the potential to complicate management of other mental disorders. This article considers this problem with the aim of increasing practitioner awareness.

Method: This article considers the literature relating to abuse of centrally acting antihistamines and presents a unique case, with features suggesting of psychological and physiological dependence following prolonged misuse of promethazine.

Results: Increased understanding of the potential problem of centrally acting antihistamine abuse and consideration of the possibility of a dependence syndrome associated with promethazine.

Conclusions: The need for vigilance for abuse potential of promethazine and other centrally acting antihistamines by doctors and pharmacists is emphasised.
Keyword Addiction dependence
Detoxification
Mental health
Substance abuse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 22 Feb 2016, 18:31:42 EST by Stephen Parker on behalf of Psychiatry - Princess Alexandra Hospital