The Interaction Between Statins and Exercise: Mechanisms and Strategies to Counter the Musculoskeletal Side Effects of This Combination Therapy

Deichmann, Richard E., Lavie, Carl J., Asher, Timothy, DiNicolantonio, James J., O'Keefe, James H. and Thompson, Paul D. (2015) The Interaction Between Statins and Exercise: Mechanisms and Strategies to Counter the Musculoskeletal Side Effects of This Combination Therapy. Ochsner Journal, 15 4: 429-437.

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Author Deichmann, Richard E.
Lavie, Carl J.
Asher, Timothy
DiNicolantonio, James J.
O'Keefe, James H.
Thompson, Paul D.
Title The Interaction Between Statins and Exercise: Mechanisms and Strategies to Counter the Musculoskeletal Side Effects of This Combination Therapy
Journal name Ochsner Journal   Check publisher's open access policy
ISSN 1524-5012
Publication date 2015
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 15
Issue 4
Start page 429
End page 437
Total pages 9
Place of publication New Orleans, United States
Publisher Ochsner Clinic
Collection year 2016
Language eng
Formatted abstract
Background: Broad indications for the use of statin medications are resulting in more patients using these therapies.
Simultaneously, healthcare professionals are strongly advocating recommendations to increase exercise training (ET) as a means of decreasing cardiovascular disease (CVD) risk and improving other parameters of fitness.
Methods: We review the literature to explore mechanisms that may increase the risk of statin/ET interactions, examine the
benefits and risks of combining ET and statin use, and offer strategies to minimize the hazards of this combination therapy.
Results: The combined use of statins and ET can result in health gains and decreased CVD risk; however, multiple factors may increase the risk of adverse events. Some of the events that have been reported with the combination of statins and ET include decreased athletic performance, muscle injury, myalgia, joint problems, decreased muscle strength, and fatigue. The type of statin, the dose, drug interactions, genetic variants, coenzyme Q10 deficiency, vitamin D deficiency, and underlying muscle diseases are among the factors that may predispose patients to intolerance of this combined therapy.
Conclusion: Effective strategies exist to help patients who may be intolerant of combined statin therapy and ET so they may
benefit from this proven therapy. Careful attention to identifying high-risk groups and strategies to prevent or treat side effects
that may occur should be employed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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Created: Mon, 22 Feb 2016, 07:43:48 EST by Matthew Lamb on behalf of School of Medicine