Cytokine-mediated loss of blood dendritic cells during Epstein-Barr virus-associated acute infectious mononucleosis: implication for immune dysregulation

Panikkar, Archana, Smith, Corey, Hislop, Andrew, Tellam, Nick, Dasari, Vijayendra, Hogquist, Kristin A., Wykes, Michelle, Moss, Denis J., Rickinson, Alan, Balfour, Henry H., Jr. and Khanna, Rajiv (2015) Cytokine-mediated loss of blood dendritic cells during Epstein-Barr virus-associated acute infectious mononucleosis: implication for immune dysregulation. Journal of Infectious Diseases, 212 12: 1957-1961. doi:10.1093/infdis/jiv340


Author Panikkar, Archana
Smith, Corey
Hislop, Andrew
Tellam, Nick
Dasari, Vijayendra
Hogquist, Kristin A.
Wykes, Michelle
Moss, Denis J.
Rickinson, Alan
Balfour, Henry H., Jr.
Khanna, Rajiv
Title Cytokine-mediated loss of blood dendritic cells during Epstein-Barr virus-associated acute infectious mononucleosis: implication for immune dysregulation
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2015-12
Year available 2015
Sub-type Article (original research)
DOI 10.1093/infdis/jiv340
Open Access Status Not Open Access
Volume 212
Issue 12
Start page 1957
End page 1961
Total pages 5
Place of publication Cary, NC United States
Publisher Oxford University Press
Collection year 2016
Language eng
Abstract Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. In the current study we demonstrated a significant loss of circulating myeloid and plasmacytoid dendritic cells (DCs) during acute IM, a loss correlated with the severity of clinical symptoms. In vitro exposure of blood DCs to acute IM plasma resulted in loss of plasmacytoid DCs, and further studies with individual cytokines showed that exposure to interleukin 10 could replicate this effect. Our data provide important mechanistic insight into dysregulated immune homeostasis during acute IM.
Keyword Herpesvirus
Acute infection
Cytokines
Immune regulation
Virus
Dendritic cells
Immune dysregulation
Antiviral immunity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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