Peptide-based synthetic vaccines

Skwarczynski, Mariusz and Toth, Istvan (2016) Peptide-based synthetic vaccines. Chemical Science, 7 2: 842-854. doi:10.1039/c5sc03892h

Author Skwarczynski, Mariusz
Toth, Istvan
Title Peptide-based synthetic vaccines
Journal name Chemical Science   Check publisher's open access policy
ISSN 2041-6520
Publication date 2016-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/c5sc03892h
Open Access Status DOI
Volume 7
Issue 2
Start page 842
End page 854
Total pages 13
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2017
Language eng
Formatted abstract
Classically all vaccines were produced using live or attenuated microorganisms or parts of them. However, the use of whole organisms, their components or the biological process for vaccine production has several weaknesses. The presence of immunologically redundant biological components or biological impurities in such vaccines might cause major problems. All the disadvantageous of traditional vaccines might be overcome via the development of fully synthetic peptide-based vaccines. However, once minimal antigenic epitopes only are applied for immunisation, the immune responses are poor. The use of an adjuvant can overcome this obstacle; however, it may raise new glitches. Here we briefly summarise the current stand on peptide-based vaccines, discuss epitope and adjuvant design, and multi-epitope and nanoparticle-based vaccine approaches. This mini review discusses also the disadvantages and benefits associated with peptide-based vaccines. It proposes possible methods to overcome the weaknesses of the synthetic vaccine strategy and suggests future directions for its development.
Keyword A streptococcal vaccines
Dendritic cells
Antigen presentation
Delivery system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 19 Feb 2016, 10:33:24 EST by Mrs Louise Nimwegen on behalf of Learning and Research Services (UQ Library)