A review of tooth discoloration after regenerative endodontic therapy

Kahler, Bill and Rossi-Fedele, Giampiero (2016) A review of tooth discoloration after regenerative endodontic therapy. Journal of Endodontics, 42 4: 563-569. doi:10.1016/j.joen.2015.12.022

Author Kahler, Bill
Rossi-Fedele, Giampiero
Title A review of tooth discoloration after regenerative endodontic therapy
Journal name Journal of Endodontics   Check publisher's open access policy
ISSN 0099-2399
Publication date 2016-04
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.joen.2015.12.022
Open Access Status Not Open Access
Volume 42
Issue 4
Start page 563
End page 569
Total pages 7
Place of publication Philadelphia, PA United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract

The American Association of Endodontists clinical considerations for regenerative therapy (April 2015) advise of the risk of the possible adverse effect of staining of teeth. It is widely acknowledged that before these guidelines were developed there was no standardized protocol for regenerative therapy, and different approaches using different materials have been reported. The purpose of this review was to undertake a systematic review of published cases to determine the incidence of reported discoloration and examine whether there was any particular association with any material.


A PubMed search was performed using key words for regenerative endodontic therapy consistent with prior published systematic reviews.


There were 80 studies identified with 379 teeth treated. Many of the studies did not report on the presence or absence of discoloration. It was noted that there was a strong association of discoloration with the use of triple antibiotic paste containing minocycline; however, discoloration was also noted when other materials were used. Unfortunately, bleaching of stained teeth was not predictably achieved in some studies.


The use of triple antibiotic paste with minocycline as the intracanal medicament should be reconsidered. Either calcium hydroxide or the double antibiotic paste of metronidazole and ciprofloxacin may limit discoloration. Mineral trioxide aggregate was also associated with discoloration. However, there is little evidence of an alternative superior material as a coronal barrier. Because discoloration is a patient-orientated outcome, further research should document and identify the incidence of discoloration in regenerative endodontic treatment.
Keyword Discoloration
Mineral trioxide aggregate
Regenerative endodontic therapy
Triple antibiotic paste
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Dentistry Publications
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