The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis

Kohn-Gaone, Julia, Gogoi-Tiwari, Jully, Ramm, Grant A., Olynyk, John K. and Tirnitz-Parker, Janina E. E. (2016) The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis. American Journal of Physiology: Gastrointestinal and Liver Physiology, 310 3: G143-G154. doi:10.1152/ajpgi.00215.2015


Author Kohn-Gaone, Julia
Gogoi-Tiwari, Jully
Ramm, Grant A.
Olynyk, John K.
Tirnitz-Parker, Janina E. E.
Title The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis
Journal name American Journal of Physiology: Gastrointestinal and Liver Physiology   Check publisher's open access policy
ISSN 1522-1547
Publication date 2016-02-02
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1152/ajpgi.00215.2015
Open Access Status Not Open Access
Volume 310
Issue 3
Start page G143
End page G154
Total pages 12
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Collection year 2016
Language eng
Abstract The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, and the metabolic syndrome has sparked interest in stem cell-like liver progenitor cells (LPCs) as potential candidates for cell therapy and tissue engineering, as an alternative approach to whole organ transplantation. However, LPCs always proliferate in chronic liver diseases with a predisposition to cancer; they have been suggested to play major roles in driving fibrosis, disease progression, and may even represent tumor-initiating cells. Hence, a greater understanding of the factors that govern their activation, communication with other hepatic cell types, and bipotential differentiation as opposed to their potential transformation is needed before their therapeutic potential can be harnessed.
Keyword Carcinogenesis
Chronic liver disease
Fibrosis
Liver progenitor cells
Liver regeneration
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes First published 25 November 2015

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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