Sex-specific attentional deficits in adult vitamin D deficient BALB/c mice

Groves, Natalie J. and Burne, Thomas H. J. (2016) Sex-specific attentional deficits in adult vitamin D deficient BALB/c mice. Physiology and Behavior, 157 94-101. doi:10.1016/j.physbeh.2016.01.033

Author Groves, Natalie J.
Burne, Thomas H. J.
Title Sex-specific attentional deficits in adult vitamin D deficient BALB/c mice
Journal name Physiology and Behavior   Check publisher's open access policy
ISSN 1873-507X
Publication date 2016-04-01
Sub-type Article (original research)
DOI 10.1016/j.physbeh.2016.01.033
Open Access Status Not Open Access
Volume 157
Start page 94
End page 101
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2017
Language eng
Abstract Epidemiological studies have shown an association between vitamin D deficiency and cognitive impairment. However, there is a paucity of preclinical data showing that vitamin D deficiency is a causal factor for impaired cognitive processing. The aim of this study was to assess two cognitive tasks, the 5 choice-serial reaction task and the 5 choice-continuous performance task in adult vitamin D (AVD) deficient BALB/c mice. Ten-week old male and female BALB/c mice were fed a control or vitamin D deficient diet for 10 weeks prior to, and during behavioural testing. We found sex-dependent impairments in attentional processing and showed that male AVD-deficient mice were less accurate, took longer to respond when making a correct choice and were more likely to make an omission, without a change in the motivation to collect reward. By contrast, female AVD-deficient mice had a reduced latency to collect reward, but no changes on any other measures compared to controls. Therefore, we have shown that in otherwise healthy adult mice, vitamin D deficiency led to mild cognitive impairment in male but not female mice and therefore this model will be useful for future investigations into unravelling the mechanism by which vitamin D affects the adult brain and cognitive function.
Keyword 5 choice serial reaction task
Animal model
Vitamin D
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
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