Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia

Van der Jeugd, Ann, Vermaercke, Ben, Halliday, Glenda M., Staufenbiel, Matthias and Gotz, Jürgen (2016) Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiology of Learning and Memory, 130 34-43. doi:10.1016/j.nlm.2016.01.007


Author Van der Jeugd, Ann
Vermaercke, Ben
Halliday, Glenda M.
Staufenbiel, Matthias
Gotz, Jürgen
Title Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia
Journal name Neurobiology of Learning and Memory   Check publisher's open access policy
ISSN 1095-9564
1074-7427
Publication date 2016-04
Sub-type Article (original research)
DOI 10.1016/j.nlm.2016.01.007
Open Access Status Not Open Access
Volume 130
Start page 34
End page 43
Total pages 10
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2017
Language eng
Abstract Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder, a major subset of which is characterized by the accumulation of abnormal forms of the protein tau, leading to impairments in motor functions as well as language and behavioral alterations. Tau58-2/B mice express human tau with the P301S mutation found in familial forms of FTLD in neurons. By assessing three age cohorts of Tau58-2/B mice in a comprehensive behavioral test battery, we found that the tauopathy animals showed age-dependent signs of impulsivity, decreased social exploration and executive dysfunction. The deficit in executive function was first limited to decreased spatial working memory, but with aging this was extended to impaired instrumental short-term memory. Tau pathology was prominent in brain regions underlying these behaviors. Thus, Tau-58-2/B mice recapitulate neurological deficits of the behavioral variant of frontotemporal dementia (bvFTD), presenting them as a suitable model to test therapeutic interventions for the amelioration of this variant.
Keyword Behavior
Executive function
Frontotemporal dementia
Frontotemporal lobar degeneration
Social exploration
Tau
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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