Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Gulia-Nuss, Monika, Nuss, Andrew B., Meyer, Jason M., Sonenshine, Daniel E., Roe, R. Michael, Waterhouse, Robert M., Sattelle, David B., de la Fuente, Jose, Ribeiro, Jose M., Megy, Karine, Thimmapuram, Jyothi, Miller, Jason R., Walenz, Brian P., Koren, Sergey, Hostetler, Jessica B., Thiagarajan, Mathangi, Joardar, Vinita S., Hannick, Linda I., Bidwell, Shelby, Hammond, Martin P., Young, Sarah, Zeng, Qiandong, Abrudan, Jenica L., Almeida, Francisca C., Ayllon, Nieves, Bhide, Ketaki, Bissinger, Brooke W., Bonzon-Kulichenko, Elena, Buckingham, Steven D., Caffrey, Daniel R., Caimano, Melissa J., Croset, Vincent, Driscoll, Timothy, Gilbert, Don, Gillespie, Joseph J., Giraldo-Calderon, Gloria I., Grabowski, Jeffrey M., Jiang, David, Khalil, Sayed M. S., Kim, Donghun, Kocan, Katherine M., Koci, Juraj, Kuhn, Richard J., Kurtti, Timothy J., Lees, Kristin, Lang, Emma G., Kennedy, Ryan C., Kwon, Hyeogsun, Perera, Rushika, Qi, Yumin, Radolf, Justin D., Sakamoto, Joyce M., Sanchez-Gracia, Alejandro, Severo, Maiara S., Silverman, Neal, Simo, Ladislav, Tojo, Marta, Tornador, Cristian, Van Zee, Janice P., Vazquez, Jesus, Vieira, Filipe G., Villar, Margarita, Wespiser, Adam R., Yang, Yunlong, Zhu, Jiwei, Arensburger, Peter, Pietrantonio, Patricia V., Barker, Stephen C., Shao, Renfu, Zdobnov, Evgeny M., Hauser, Frank, Grimmelikhuijzen, Cornelis J. P., Park, Yoonseong, Rozas, Julio, Benton, Richard, Pedra, Joao H. F., Nelson, David R., Unger, Maria F., Tubio, Jose M. C., Tu, Zhijian, Robertson, Hugh M., Shumway, Martin, Sutton, Granger, Wortman, Jennifer R., Lawson, Daniel, Wikel, Stephen K., Nene, Vishvanath M., Fraser, Claire M., Collins, Frank H., Birren, Bruce, Nelson, Karen E., Caler, Elisabet and Hill, Catherine A. (2016) Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nature Communications, 7 10507.1-10507.13. doi:10.1038/ncomms10507


Author Gulia-Nuss, Monika
Nuss, Andrew B.
Meyer, Jason M.
Sonenshine, Daniel E.
Roe, R. Michael
Waterhouse, Robert M.
Sattelle, David B.
de la Fuente, Jose
Ribeiro, Jose M.
Megy, Karine
Thimmapuram, Jyothi
Miller, Jason R.
Walenz, Brian P.
Koren, Sergey
Hostetler, Jessica B.
Thiagarajan, Mathangi
Joardar, Vinita S.
Hannick, Linda I.
Bidwell, Shelby
Hammond, Martin P.
Young, Sarah
Zeng, Qiandong
Abrudan, Jenica L.
Almeida, Francisca C.
Ayllon, Nieves
Bhide, Ketaki
Bissinger, Brooke W.
Bonzon-Kulichenko, Elena
Buckingham, Steven D.
Caffrey, Daniel R.
Caimano, Melissa J.
Croset, Vincent
Driscoll, Timothy
Gilbert, Don
Gillespie, Joseph J.
Giraldo-Calderon, Gloria I.
Grabowski, Jeffrey M.
Jiang, David
Khalil, Sayed M. S.
Kim, Donghun
Kocan, Katherine M.
Koci, Juraj
Kuhn, Richard J.
Kurtti, Timothy J.
Lees, Kristin
Lang, Emma G.
Kennedy, Ryan C.
Kwon, Hyeogsun
Perera, Rushika
Qi, Yumin
Radolf, Justin D.
Sakamoto, Joyce M.
Sanchez-Gracia, Alejandro
Severo, Maiara S.
Silverman, Neal
Simo, Ladislav
Tojo, Marta
Tornador, Cristian
Van Zee, Janice P.
Vazquez, Jesus
Vieira, Filipe G.
Villar, Margarita
Wespiser, Adam R.
Yang, Yunlong
Zhu, Jiwei
Arensburger, Peter
Pietrantonio, Patricia V.
Barker, Stephen C.
Shao, Renfu
Zdobnov, Evgeny M.
Hauser, Frank
Grimmelikhuijzen, Cornelis J. P.
Park, Yoonseong
Rozas, Julio
Benton, Richard
Pedra, Joao H. F.
Nelson, David R.
Unger, Maria F.
Tubio, Jose M. C.
Tu, Zhijian
Robertson, Hugh M.
Shumway, Martin
Sutton, Granger
Wortman, Jennifer R.
Lawson, Daniel
Wikel, Stephen K.
Nene, Vishvanath M.
Fraser, Claire M.
Collins, Frank H.
Birren, Bruce
Nelson, Karen E.
Caler, Elisabet
Hill, Catherine A.
Title Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Formatted title
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2016-02-09
Sub-type Article (original research)
DOI 10.1038/ncomms10507
Open Access Status DOI
Volume 7
Start page 10507.1
End page 10507.13
Total pages 13
Place of publication London, United Kingdom
Publisher Nature Publishing
Collection year 2017
Language eng
Formatted abstract
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ~57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 12 Feb 2016, 12:06:04 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences