Paternal age as a risk factor for psychosis and schizophrenia: Findings from Denmark, Sweden and Australia

El-Saadi, O., Saha, S., Welham, J., Chant, D., Mortensen, P.B., Pedersen, C.B., Cantor-Graae, E., McNeil, T.F., OCallaghan, E. and McGrath, J. (2002). Paternal age as a risk factor for psychosis and schizophrenia: Findings from Denmark, Sweden and Australia. In: Schizophrenia Research: Abstracts of the XIth Biennial Winter Workshop on Schizophrenia. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (248-248). 24 February - 1 March, 2002. doi:10.1016/S0920-9964(01)00381-4


Author El-Saadi, O.
Saha, S.
Welham, J.
Chant, D.
Mortensen, P.B.
Pedersen, C.B.
Cantor-Graae, E.
McNeil, T.F.
OCallaghan, E.
McGrath, J.
Title of paper Paternal age as a risk factor for psychosis and schizophrenia: Findings from Denmark, Sweden and Australia
Conference name XIth Biennial Winter Workshop on Schizophrenia
Conference location Davos, Switzerland
Conference dates 24 February - 1 March, 2002
Proceedings title Schizophrenia Research: Abstracts of the XIth Biennial Winter Workshop on Schizophrenia   Check publisher's open access policy
Journal name Schizophrenia Research   Check publisher's open access policy
Place of Publication Amsterdam
Publisher Elsevier
Publication Year 2002
Sub-type Poster
DOI 10.1016/S0920-9964(01)00381-4
ISSN 0920-9964
Volume 53
Issue 3, Supplement 1
Start page 248
End page 248
Total pages 1
Language eng
Abstract/Summary The offspringof older fathers have an increased risk of various disorders that may be due to the accumulation of DNA mutations during spermatogenesis. Previous studies have suggested increased paternal age may be a risk factor for schizophrenia. The aim of the current study was to examine paternal age as a risk factor for schizophrenia andror psychosis. We used data from three sources: a population-based cohort studyŽDenmark., and two case-control studiesŽSweden and Australia.. In the Danish and Australian studies, we examined both psychosis and schizophrenia. In the Swedish study we examined psychosis only. After controllingfor the effect of maternal age, increased paternal age was significantly associated with increased risk of both psychosis and schizophrenia in the Danish study and of psychosis in the Swedish study. The Australian study found no association between paternal age and risk of psychosis or schizophrenia. In all three studies the relationship between paternal age and risk of disorder in the offspring was AUB-shaped. In addition to an increased risk for the offspringof older father Ž)35 years., there was a non-significant increase for the offspringof fathers aged less than 20 years. The possible role of paternally derived DNA mutations andror other psychosocial factors associated with older paternal age warrants further research. The ‘U’-shaped relationship suggests that factors other than DNA mutations may warrant consideration in this research. The Stanley Foundation supported this project.
Subjects 110319 Psychiatry (incl. Psychotherapy)
111714 Mental Health
Keyword Psychiatry
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Mon, 13 Aug 2007, 22:49:38 EST