ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor

Lavin, Martin F., Kozlov, Sergei, Gatei, Magtouf and Kijas, Amanda W. (2015) ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor. Biomolecules, 5 4: 2877-2902. doi:10.3390/biom5042877


Author Lavin, Martin F.
Kozlov, Sergei
Gatei, Magtouf
Kijas, Amanda W.
Title ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor
Journal name Biomolecules   Check publisher's open access policy
ISSN 2218-273X
Publication date 2015-10-23
Sub-type Article (original research)
DOI 10.3390/biom5042877
Open Access Status DOI
Volume 5
Issue 4
Start page 2877
End page 2902
Total pages 26
Place of publication Basel, Switzerland
Publisher MDPI
Collection year 2016
Language eng
Abstract The recognition, signalling and repair of DNA double strand breaks (DSB) involves the participation of a multitude of proteins and post-translational events that ensure maintenance of genome integrity. Amongst the proteins involved are several which when mutated give rise to genetic disorders characterised by chromosomal abnormalities, cancer predisposition, neurodegeneration and other pathologies. ATM (mutated in ataxia-telangiectasia (A-T) and members of the Mre11/Rad50/Nbs1 (MRN complex) play key roles in this process. The MRN complex rapidly recognises and locates to DNA DSB where it acts to recruit and assist in ATM activation. ATM, in the company of several other DNA damage response proteins, in turn phosphorylates all three members of the MRN complex to initiate downstream signalling. While ATM has hundreds of substrates, members of the MRN complex play a pivotal role in mediating the downstream signalling events that give rise to cell cycle control, DNA repair and ultimately cell survival or apoptosis. Here we focus on the interplay between ATM and the MRN complex in initiating signaling of breaks and more specifically on the adaptor role of the MRN complex in mediating ATM signalling to downstream substrates to control different cellular processes.
Keyword DNA double strand breaks
Oxidative stress
ATM activation
Mre11/Rad50/Nbs1 complex
Phosphorylation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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Created: Thu, 11 Feb 2016, 13:15:12 EST by Roheen Gill on behalf of UQ Centre for Clinical Research