Agreement in the fluctuations of schizophrenia birth rates in Finland, Denmark, the Netherlands, Scotland, England and Wales

McGrath, J., Chant, D., Sham, P., Selten, J.P., Mortensen, P.B., Suvisaari, J., McNeil, T. and Kendell, R. (2002). Agreement in the fluctuations of schizophrenia birth rates in Finland, Denmark, the Netherlands, Scotland, England and Wales. In: Schizophrenia research: Abstracts of the XIth Biennial Winter Workshop on Schizophrenia. The XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (245-245). 24 February – 1 March, 2002. doi:10.1016/S0920-9964(01)00381-4


Author McGrath, J.
Chant, D.
Sham, P.
Selten, J.P.
Mortensen, P.B.
Suvisaari, J.
McNeil, T.
Kendell, R.
Title of paper Agreement in the fluctuations of schizophrenia birth rates in Finland, Denmark, the Netherlands, Scotland, England and Wales
Conference name The XIth Biennial Winter Workshop on Schizophrenia
Conference location Davos, Switzerland
Conference dates 24 February – 1 March, 2002
Proceedings title Schizophrenia research: Abstracts of the XIth Biennial Winter Workshop on Schizophrenia   Check publisher's open access policy
Journal name Schizophrenia Research   Check publisher's open access policy
Place of Publication Amsterdam
Publisher Elsevier
Publication Year 2002
DOI 10.1016/S0920-9964(01)00381-4
ISSN 0920-9964
Volume 53
Issue 3 Supplement 1
Start page 245
End page 245
Total pages 1
Language eng
Formatted Abstract/Summary
Background:
Schizophrenia birth rates have both within-year
variationŽseason of the birth effect.and between-year variation.
However, it has not been clear how to identify AtrueB fluctuations
in between-year schizophrenia birth ratesŽa ‘signal’.from random
background fluctuationsŽ‘noise’.. We propose that if birth rates
time series agree between nations, then these fluctuations are more
likely to be signals rather than noise. Here we examine agreement
in schizophrenia birth rates in five European sites.

Methods:

Schizophrenia birth rates were calculated from mental
health registers from Denmark, Finland, the Netherlands, England
and Wales, Scotland and Queensland. The slopes in
schizophrenia birth rates were examined in pair-wise comparisons
and assessed for monthly agreement using the kappa statistic.

Results:

For the European sites, six of the 10 pair-wise
comparisons were in significant agreement. All of these associations
were positiveŽkappass0.17–0.24.. Schizophrenia births in
England and Wales were significantly associated with the followingsites;
Netherlands, Denmark and Finland. Scotland was significantly
associated with the Netherlands and Finland; The Netherlands
were also significantly associated with Denmark. By way of
contrast, schizophrenia birth rates in Queensland were not associated
with any of the Northern Hemisphere sites.

Conclusions:

Environmental risk factors that fluctuate over
time influence schizophrenia birth rates in adjacent countries in a
coherent fashion. We will be examininga range of variables
related to infection, nutrition and climate in order understand these
fluctuations.
The Stanley Foundation supported this project.
Subjects 110319 Psychiatry (incl. Psychotherapy)
111714 Mental Health
Keyword Psychiatry
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Oral presentation

 
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Created: Mon, 13 Aug 2007, 22:49:33 EST