The co-segregation of psychosis and selected physical disorders within families of patients with psychosis versus well controls

El-Saadi, O., Chant, D., Saha, S., Welham, J. and McGrath, J. (2002). The co-segregation of psychosis and selected physical disorders within families of patients with psychosis versus well controls. In: Schizophrenia research: Abstracts of the XIth Biennial Winter Workshop on Schizophrenia. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (80-81). 24 February - 1 March, 2002. doi:10.1016/S0920-9964(01)00381-4


Author El-Saadi, O.
Chant, D.
Saha, S.
Welham, J.
McGrath, J.
Title of paper The co-segregation of psychosis and selected physical disorders within families of patients with psychosis versus well controls
Conference name XIth Biennial Winter Workshop on Schizophrenia
Conference location Davos, Switzerland
Conference dates 24 February - 1 March, 2002
Proceedings title Schizophrenia research: Abstracts of the XIth Biennial Winter Workshop on Schizophrenia   Check publisher's open access policy
Journal name Schizophrenia Research   Check publisher's open access policy
Place of Publication Amsterdam
Publisher Elsevier
Publication Year 2002
Sub-type Poster
DOI 10.1016/S0920-9964(01)00381-4
ISSN 0920-9964
Volume 53
Issue 3, Supplement 1
Start page 80
End page 81
Total pages 2
Language eng
Abstract/Summary While it has been reported that individuals with psychosis are at increased or decreased risk of various physical disorders such as cancer and rheumatoid arthritis, there has been less research on the co-segregation of physical disorders within the first-degree relatives of those with psychosis compared to relatives of well controls. The aim of this study was to examine these issues in an epidemiologically informed catchment-area based case-control study. Patients with psychosis were drawn from a prevalence study undertaken as part of the Australian National Mental Health Survey. In addition, we recruited well controls who resided in the same catchment area. For each subject, we drew pedigrees and used a structured checklist to assess the presence of selected psychiatric disorders, and selected disorders such as multiple sclerosis, epilepsy, spina bifida, thyroid disorders, diabetes, asthma and eczema. Data based on pedigrees from 293 individuals with psychosis and 292 well controls was available. As expected, the odds of havingschizophrenia and affective disorders were significantly increased in the families of cases versus controls. The odds of havingeczema were significantly reduced in the relatives of those with psychosis. All other disorders occurred with equal frequency in cases versus control pedigrees. Current theories of eczema suggest that an absence of early life exposure to antigens and infectious agents may fail to prime the na¨ıve immune system, and leave the person at increased risk of eczema. The results of this study suggest that genetic andror environmental factors that facilitate psychosis may protect against eczema. The Stanley Foundation supported this project.
Subjects 110319 Psychiatry (incl. Psychotherapy)
111714 Mental Health
Keyword Psychiatry
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Mon, 13 Aug 2007, 22:48:55 EST