Clinical features, aetiology and outcome of empyema in children in the north east of England

Eastham, K. M., Freeman, R., Kearns, A. M., Eltringham, G., Clark, J., Leeming, J. and Spencer, D. A. (2004) Clinical features, aetiology and outcome of empyema in children in the north east of England. Thorax, 59 6: 522-525. doi:10.1136/thx.2003.016105


Author Eastham, K. M.
Freeman, R.
Kearns, A. M.
Eltringham, G.
Clark, J.
Leeming, J.
Spencer, D. A.
Title Clinical features, aetiology and outcome of empyema in children in the north east of England
Journal name Thorax   Check publisher's open access policy
ISSN 0040-6376
1468-3296
Publication date 2004-06
Sub-type Article (original research)
DOI 10.1136/thx.2003.016105
Open Access Status Not yet assessed
Volume 59
Issue 6
Start page 522
End page 525
Total pages 4
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Background: The incidence of empyema in children in the UK is increasing. The reason for this is unclear. A prospective study was undertaken to investigate the clinical features, aetiology, and outcome of cases of empyema and parapneumonic effusion presenting to a tertiary paediatric respiratory centre between February 1997 and August 2001.

Method: Routine bacterial culture of blood and pleural fluid was performed for 47 cases. Forty three pleural fluid specimens, culture negative for pneumococcus, were analysed for pneumococccal DNA by real time polymerase chain reaction (PCR). Penicillin susceptibility was determined for DNA positive specimens using complementary PCR assay. Capsular serotype specific antigen detection was by enzyme immunoassay (EIA) using monoclonal antibodies to serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. Clinical data were obtained from patient notes, supplemented by a postal questionnaire.

Results: The median (range) age of the patients was 5.6 (0.6-16.9) years and 70% were male. The median (range) duration of illness before referral to hospital was 5 (0-25) days. Forty five (96%) had received antibiotics before referral; 32 (68%) required decortication and eight (21%) thoracocentesis. Median postoperative stay was 4 days (2-8). Thirty two (75%) pneumococcal culture negative specimens were pneumococcal DNA positive; 17 (53%) of these were serotype 1. All were penicillin sensitive.

Conclusions: Pneumococcus is the major pathogen in childhood empyema and serotype 1 is the prevalent serotype. This has implications for vaccine development and immunisation strategy as the current 7-valent pneumococcal conjugate vaccine does not protect against serotype 1.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 128 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 148 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 10 Feb 2016, 10:49:19 EST by System User on behalf of Learning and Research Services (UQ Library)