Investigation for complement deficiency following meningococcal disease

Hoare, S., El-Shazali, O., Clark, J. E., Fay, A. and Cant, A. J. (2002) Investigation for complement deficiency following meningococcal disease. Archives of Disease in Childhood, 86 3: 215-217. doi:10.1136/adc.86.3.215

Author Hoare, S.
El-Shazali, O.
Clark, J. E.
Fay, A.
Cant, A. J.
Title Investigation for complement deficiency following meningococcal disease
Journal name Archives of Disease in Childhood   Check publisher's open access policy
ISSN 0003-9888
Publication date 2002-03
Sub-type Article (original research)
DOI 10.1136/adc.86.3.215
Open Access Status Not yet assessed
Volume 86
Issue 3
Start page 215
End page 217
Total pages 3
Place of publication London, WC1H 9JR United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Background and aims: The incidence of complement abnormalities in the UK is not known. It is suggested in at least three major paediatric textbooks to test for abnormalities of the complement system following meningococcal disease (MCD).

Methods: Over a four year period, surviving children with a diagnosis of MCD had complement activity assessed. A total of 297 children, aged 2 months to 16 years were screened.

Results: All children except one had disease caused by B or C serogroups. One child, with group B meningococcal septicaemia (complicated by disseminated intravascular coagulation and who required ventilation and inotropic support) was complement deficient. C2 deficiency was subsequently diagnosed. She had other major pointers towards an immunological abnormality prior to her MCD.

Conclusion: It is unnecessary to screen all children routinely following MCD if caused by group B or C infection. However, it is important to assess the previous health of the child and to investigate appropriately if there have been previous suspicious infections, abnormal course of infective illnesses, or if this is a repeated episode of neisserial infection.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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