Emergence of pneumococcal 19A empyema in UK children

Thomas, Matthew F., Sheppard, Carmen L., Guiver, Malcolm, Slack, Mary P. E., George, Robert C., Gorton, Russell, Paton, James Y., Simmister, Clare, Cliff, David, Elemraid, Mohamed A., Clark, Julia E., Rushton, Stephen P. and Spencer, David Anthony (2012) Emergence of pneumococcal 19A empyema in UK children. Archives of Disease in Childhood, 97 12: 1070-1072. doi:10.1136/archdischild-2012-301790

Author Thomas, Matthew F.
Sheppard, Carmen L.
Guiver, Malcolm
Slack, Mary P. E.
George, Robert C.
Gorton, Russell
Paton, James Y.
Simmister, Clare
Cliff, David
Elemraid, Mohamed A.
Clark, Julia E.
Rushton, Stephen P.
Spencer, David Anthony
Title Emergence of pneumococcal 19A empyema in UK children
Journal name Archives of Disease in Childhood   Check publisher's open access policy
ISSN 0003-9888
Publication date 2012-12
Year available 2012
Sub-type Article (original research)
DOI 10.1136/archdischild-2012-301790
Open Access Status Not yet assessed
Volume 97
Issue 12
Start page 1070
End page 1072
Total pages 3
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Introduction: Invasive pneumococcal disease due to serotype 19A has become a major concern, particularly in the USA and Asia. We describe the characteristics of pneumococcal serotype 19A related empyema and changes in its incidence in the UK.

Methods: Data from paediatric empyema patients between September 2006 and March 2011 were collected from 17 respiratory centres in the UK. Pneumococcal serotypes were identified as part of the Health Protection Agency enhanced paediatric empyema surveillance programme.

Results: Four serotypes accounted for over 80% of 136 cases (Serotype 1 : 43%, 3 : 21%, 7 : 11% and 19A:10%). The incidence of empyema due to serotype 19A quadrupled from 0.48 (0.16-1.13) cases per million children in 2006/2007 to 2.02 (1.25-3.09) in 2010/2011. Severity of disease was significantly increased in children with 19A infection when compared to other serotypes.

Conclusions: The incidence of empyema due to pneumococcal serotype 19A infection has increased significantly and is associated with substantial morbidity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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