Testing replication of a 5-SNP set for general cognitive ability in six population samples

Luciano, Michelle, Lind, Penelope A., Deary, Ian J., Payton, Antony, Posthuma, Danielle, Butcher, Lee M., Bochdanovits, Zoltan, Whalley, Lawrence J., Visscher, Peter M., Harris, Sarah E., Polderman, Tinca J. C., Davis, Oliver S. P., Wright, Margaret J., Starr, John M., de Geus, Eco J. C., Bates, Timothy C., Montgomery, Grant W., Boomsma, Dorret I., Martin, Nicholas G. and Plomin, Robert (2008) Testing replication of a 5-SNP set for general cognitive ability in six population samples. European Journal of Human Genetics, 16 11: 1388-1395. doi:10.1038/ejhg.2008.100

Author Luciano, Michelle
Lind, Penelope A.
Deary, Ian J.
Payton, Antony
Posthuma, Danielle
Butcher, Lee M.
Bochdanovits, Zoltan
Whalley, Lawrence J.
Visscher, Peter M.
Harris, Sarah E.
Polderman, Tinca J. C.
Davis, Oliver S. P.
Wright, Margaret J.
Starr, John M.
de Geus, Eco J. C.
Bates, Timothy C.
Montgomery, Grant W.
Boomsma, Dorret I.
Martin, Nicholas G.
Plomin, Robert
Title Testing replication of a 5-SNP set for general cognitive ability in six population samples
Journal name European Journal of Human Genetics   Check publisher's open access policy
ISSN 1018-4813
Publication date 2008
Sub-type Article (original research)
DOI 10.1038/ejhg.2008.100
Open Access Status Not yet assessed
Volume 16
Issue 11
Start page 1388
End page 1395
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P = 0.06) in the direction of the original finding, but results from the other samples (N = 205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P = 0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied.
Keyword SNP set
Cognitive ability
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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